Autor segons l'article: Paz-Graniel, Indira; Garcia-Gavilan, Jesus F; Ros, Emilio; Connelly, Margery A; Babio, Nancy; Mantzoros, Christos S; Salas-Salvado, Jordi
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge
Paraules clau: T2dm Risk factors Questionnaire Pattern Nmr lipoproteins Mediterranean diet Me Magnetic resonance spectroscopy Lipoproteins Insulin resistance Humans Glucose Diet, mediterranean Diabetes mellitus Cross-sectional studies Cardiovascular diseases Biomarkers Atherogenic lipids Atherogenic lipid Aged
Resum: Background: The Mediterranean diet (MedDiet) has been related to a decreased risk of cardiovascular disease (CVD) and diabetes. Objectives: We aimed to prospectively assess the relationship between adherence to the MedDiet and advanced lipoprotein subclass profiles and glucose metabolism and inflammation markers, as determined by nuclear magnetic resonance (NMR) spectroscopy. Design: We conducted cross-sectional and longitudinal analyses within the framework of the PREvencion con DIeta MEDiterranea study in 196 par-ticipants from the Reus-Tarragona center. Adherence to the MedDiet was assessed using a 14-item validated questionnaire [Mediterranean Diet Adherence Score (MEDAS)]. Plasma lipoprotein subclasses and molecular metabolite profiles were determined using NMR spectra collected on a Vantera Clinical Analyzer at baseline and after 1 y of follow-up. Baseline and 1-y categories of MEDAS were related to measures of lipoprotein atherogenicity and diabetes risk using multivariable-adjusted analysis of covariance models. Results: Compared with participants in the lowest category of baseline MEDAS, those in the highest category showed higher concentrations of total high-density lipoprotein (HDL) particles and H1P HDL, lower concentrations of very low-density lipoprotein (VLDL)-triglyceride, smaller size of VLDL, and lower concentrations of very large VLDL, as well as lower concentrations of branched-chain amino acids, leucine, and GlycA and reduced Diabetes Risk Index (DRI) scores. In addition, participants who increased by 3 or more points in their 1-y MEDAS showed an increase in concentrations of H7P-HDL, H5P-HDL, and citrate, and reduced acetone and DRI scores compared with those with lesser adherence increases. Conclusions: In older adults at high cardiometabolic risk, higher MEDAS was associated with modest beneficial changes in lipoprotein and glucose metabolism. The results suggest that lipoprotein subclass distribution and glycemic control are potential mechanisms behind the well-known salutary effects of MedDiet on CVD and diabetes risk. Future clinical trials exploring the effects of the MedDiet on advanced lipoprotein subclass profiles and glucose metabolism markers are needed to confirm the results of our study.
Àrees temàtiques: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador de l'autor: 0000-0002-3707-5255 0000-0002-3204-6877 0000-0002-3707-5255 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Data d'alta del registre: 2025-02-08
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: American Journal Of Clinical Nutrition. 119 (1): 108-116
Referència de l'ítem segons les normes APA: Paz-Graniel, Indira; Garcia-Gavilan, Jesus F; Ros, Emilio; Connelly, Margery A; Babio, Nancy; Mantzoros, Christos S; Salas-Salvado, Jordi (2024). Adherence to the Mediterranean diet and nuclear magnetic resonance spectroscopy biomarkers in older individuals at high cardiovascular disease risk: cross-sectional and longitudinal analyses. American Journal Of Clinical Nutrition, 119(1), 108-116. DOI: 10.1016/j.ajcnut.2023.11.003
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2024
Tipus de publicació: Journal Publications
Repositori URV