Autor segons l'article: Gomes, Rita V C; Borrull, Silvia; Pereira, Alicia; Dias, Marta; Cereja, Rui; Barata, Marisa; Pousao-Ferreira, Pedro; Faria, Ana M; Pocurull, Eva; Marce, Rosa Maria; Marques, Antonio; Maulvault, Ana Luisa
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Marcé Recasens, Rosa Maria / Pocurull Aixala, Eva
Paraules clau: Bas Chronic exposure Coastal Ecotoxicit Ecotoxicity Emerging contaminants Endocrine disruption Enzymes High production volume chemicals Organophosphate esters Plasticizers Water
Resum: High Production Volume Chemicals (HPVCs) are contaminants that pose serious threats to aquatic environments and species that inhabit them, given their massive production and ubiquitous distribution across biological compartments. Among them, organophosphate esters (OPEs) are of particular concern, as they are widely used as plasticizers and flame-retardants, and linked to various forms of toxicity in marine organisms. In this study, we investigated the ecotoxicological response of juvenile gilthead seabream Sparus aurata to the OPE tris (2chloroisopropyl) phosphate (TCPP) following chronic dietary exposure to three different concentrations (low, D1: 0.2 mg kg-1; ecologically relevant, D2: 2 mg kg-1; and high, D3: 10 mg kg- 1). Different biomarkers indicative of antioxidant defence mechanisms (catalase, CAT, glutathione S-transferase, GST, activities), metabolism (citrate synthase, CS, lactate dehydrogenase, LDH, activities) and endocrine disruption (vitellogenin content, VTG), as well as cell (lipid peroxidation levels, LPO) and protein damage (ubiquitin content, UBI) were analyzed in liver and muscle to assess TCPP toxicity. High concentrations of TCPP affected S. aurata growth, but not overall fitness condition. Furthermore, metabolic disruption and severe oxidative damages were observed, regardless of exposure dose. VTG content significantly decreased after exposure to all TCPP dosages, indicating a possible masculinization effect. These findings provide new insights to the scientific knowledge on TCPP ecotoxicological attributes and impacts on marine ichthyofauna. In addition, our results confirm the relevance of conducting integrated multi-biomarker approaches to disclose the ecotoxicological effects of poorly studied chemical contaminants and, ultimately, implement wastewater treatment strategies and legislation to protect marine ecosystems from pollution.
Àrees temàtiques: Administração pública e de empresas, ciências contábeis e turismo Aquatic science Astronomia / física Biodiversidade Biotecnología Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Engenharias i Engenharias ii Engenharias iii Engenharias iv Ensino Environmental sciences Farmacia Geociências Geografía Interdisciplinar Marine & freshwater biology Matemática / probabilidade e estatística Medicina i Medicina ii Medicina veterinaria Nutrição Oceanography Planejamento urbano e regional / demografia Pollution Química Saúde coletiva Zootecnia / recursos pesqueiros
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: rosamaria.marce@urv.cat eva.pocurull@urv.cat
Identificador de l'autor: 0000-0002-5667-2899 0000-0001-5123-995X
Data d'alta del registre: 2025-03-08
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: Marine Pollution Bulletin. 213 117628-
Referència de l'ítem segons les normes APA: Gomes, Rita V C; Borrull, Silvia; Pereira, Alicia; Dias, Marta; Cereja, Rui; Barata, Marisa; Pousao-Ferreira, Pedro; Faria, Ana M; Pocurull, Eva; Marc (2025). Ecotoxicological responses of marine fish to the organophosphate flame-retardant tris (2-chloroisopropyl) phosphate (TCPP) dietary exposure: Juvenile gilthead seabream (Sparus aurata) as a case study. Marine Pollution Bulletin, 213(), 117628-. DOI: 10.1016/j.marpolbul.2025.117628
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2025
Tipus de publicació: Journal Publications
Repositori URV