Articles producció científica> Medicina i Cirurgia

Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids

  • Identification data

    Identifier: PC:1451
    Authors:
    López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme PiñolAlba MaciàMaría-Paz RomeroRosa SolàLaura RubióMaria-José Motilva
    Abstract:
    This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
  • Others:

    Author, as appears in the article.: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme Piñol; Alba Macià; María-Paz Romero; Rosa Solà; Laura Rubió; Maria-José Motilva
    Department: Medicina i Cirurgia
    URV's Author/s: PEDRET FIGUEROLA, ANNA, SOLÀ ALBERICH, ROSA MARIA
    Keywords: Hydroxytyrosol Microbial catabolism Metabolic pathways
    Abstract: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
    Research group: Unitat de Recerca de Lípids i Arteriosclerosi
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1756-4646
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2016-04-19
    Last page: 63
    Journal volume: 22
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.jff.2016.01.030
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 52
    Publication Type: Article Artículo Article
  • Keywords:

    Hydroxytyrosol
    Metabolisme microbià
    Vies metabòliques
    Hydroxytyrosol
    Microbial catabolism
    Metabolic pathways
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1756-4646
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