Author, as appears in the article.: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme Piñol; Alba Macià; María-Paz Romero; Rosa Solà; Laura Rubió; Maria-José Motilva
Department: Medicina i Cirurgia
URV's Author/s: PEDRET FIGUEROLA, ANNA, SOLÀ ALBERICH, ROSA MARIA
Keywords: Hydroxytyrosol Microbial catabolism Metabolic pathways
Abstract: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
Research group: Unitat de Recerca de Lípids i Arteriosclerosi
Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1756-4646
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2016-04-19
Last page: 63
Journal volume: 22
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
Article's DOI: 10.1016/j.jff.2016.01.030
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 52
Publication Type: Article Artículo Article
Repositori URV