Author, as appears in the article.: Montserrat Giralt; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; María-Rosa Nogués; Isabel Medina
Department: Ciències Mèdiques Bàsiques
URV's Author/s: GIRALT BATISTA, MONTSERRAT; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; NOGUÉS LLORT, MARIA ROSA; Isabel Medina
Keywords: Metabolism FATTY ACIDS Biomarkers
Abstract: The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.
Research group: Farmacobiologia Cel.lular
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0308-8146
Author identifier: S/D; S/D; S/D; S/D; S/D; S/D; S/D; S/D
Record's date: 2016-04-27
Last page: 203
Journal volume: 205
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0308814616303715?via%3Dihub
Article's DOI: 10.1016/j.foodchem.2016.03.020
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 196
Publication Type: Article Artículo Article
Repositori URV