Articles producció científica> Ciències Mèdiques Bàsiques

Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model

  • Identification data

    Identifier: PC:1459
    Handle: https://hdl.handle.net/20.500.11797/PC1459
    Authors:
    Montserrat GiraltGabriel DasilvaManuel PazosEduardo García-EgidoJara Pérez-JiménezJosep Lluis TorresMaría-Rosa NoguésIsabel Medina
    Abstract:
    The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.

  • Others:

    Author, as appears in the article.: Montserrat Giralt; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; María-Rosa Nogués; Isabel Medina
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: GIRALT BATISTA, MONTSERRAT; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; NOGUÉS LLORT, MARIA ROSA; Isabel Medina
    Keywords: Metabolism FATTY ACIDS Biomarkers
    Abstract: The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.
    Research group: Farmacobiologia Cel.lular
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0308-8146
    Author identifier: S/D; S/D; S/D; S/D; S/D; S/D; S/D; S/D
    Record's date: 2016-04-27
    Last page: 203
    Journal volume: 205
    Papper version: info:eu-repo/semantics/submittedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 196
    Publication Type: Article Artículo Article

  • Keywords:

    METABOLISME
    ÀCIDS GRASSOS
    Metabolism
    FATTY ACIDS
    Biomarkers
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    0308-8146

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