Articles producció científica> Ciències Mèdiques Bàsiques

Virulence and resistance to antifungal therapies of Scopulariopsis species

  • Identification data

    Identifier: PC:1513
    Authors:
    Katihuska ParedesJavier CapillaEmilio MayayoJosep Guarro
    Abstract:
    Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
  • Others:

    Author, as appears in the article.: Katihuska Paredes; Javier Capilla; Emilio Mayayo; Josep Guarro
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: PAREDES AGUILAR, KATIHUSKA VIVIANA; CAPILLA LUQUE, JAVIER; MAYAYO ARTAL, EMILIO MANUEL; GUARRO ARTIGAS, JOSEP
    Abstract: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
    Research group: Unitat de Micologia i Microbiologia Ambiental
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0066-4804
    Author identifier: 0000-0002-0765-6403; 0000-0002-7839-7568
    Record's date: 2016-05-04
    Last page: 2068
    Journal volume: 60
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://aac.asm.org/content/60/4/2063
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1128/AAC.02275-15
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 2063
    Publication Type: Article Artículo Article
  • Keywords:

    Fongs patògens
    Fongs -- Resistència als medicaments
    Agents antifungics
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    0066-4804
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