Author, as appears in the article.: Katihuska Paredes; Javier Capilla; Emilio Mayayo; Josep Guarro
Department: Ciències Mèdiques Bàsiques
URV's Author/s: PAREDES AGUILAR, KATIHUSKA VIVIANA; CAPILLA LUQUE, JAVIER; MAYAYO ARTAL, EMILIO MANUEL; GUARRO ARTIGAS, JOSEP
Abstract: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
Research group: Unitat de Micologia i Microbiologia Ambiental
Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0066-4804
Author identifier: 0000-0002-0765-6403; 0000-0002-7839-7568
Record's date: 2016-05-04
Last page: 2068
Journal volume: 60
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://aac.asm.org/content/60/4/2063
Article's DOI: 10.1128/AAC.02275-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 2063
Publication Type: Article Artículo Article
Repositori URV