Articles producció científica> Bioquímica i Biotecnologia

Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors after a Long-Term Follow-Up in the PREDIMED Study

  • Identification data

    Identifier: PC:1556
    Authors:
    Jordi Salas-SalvadóXiaohui GuoAnna Tresserra-RimbauRamón EstruchMiguel A. Martínez-GonzálezAlexander Medina-RemónOlga CastañerDolores CorellaRosa M. Lamuela-Raventós
    Abstract:
    DOI: 10.1155/2016/2572606 URL: http://www.hindawi.com/journals/omcl/2016/2572606/
  • Others:

    Author, as appears in the article.: Jordi Salas-Salvadó; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
    Department: Bioquímica i Biotecnologia
    URV's Author/s: SALAS SALVADÓ, JORGE; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
    Keywords: Cholesterol Blood pressure Biomarkers
    Abstract: Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = - 8.563; P = 0.007), glucose concentration (β = - 4.164; P = 0.036), and diastolic blood pressure (β = - 1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1942-0900
    Author identifier: 0000-0003-2700-7459; n/a; 0000-0002-7022-9041; 0000-0003-1260-4445; n/a; 0000-0003-1985-7592; n/a; 0000-0002-2366-4104; 0000-0002-1287-4560
    Record's date: 2016-06-10
    Journal volume: 2016
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.hindawi.com/journals/omcl/2016/2572606/
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1155/2016/2572606
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: Article number 2572606
    Publication Type: Article Artículo Article
  • Keywords:

    Colesterol
    Pressió arterial
    Marcadors bioquímics
    Cholesterol
    Blood pressure
    Biomarkers
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    1942-0900
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