Author, as appears in the article.: Jordi Salas-Salvadó; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Department: Bioquímica i Biotecnologia
URV's Author/s: SALAS SALVADÓ, JORGE; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Keywords: Cholesterol Blood pressure Biomarkers
Abstract: Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = - 8.563; P = 0.007), glucose concentration (β = - 4.164; P = 0.036), and diastolic blood pressure (β = - 1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1942-0900
Author identifier: 0000-0003-2700-7459; n/a; 0000-0002-7022-9041; 0000-0003-1260-4445; n/a; 0000-0003-1985-7592; n/a; 0000-0002-2366-4104; 0000-0002-1287-4560
Record's date: 2016-06-10
Journal volume: 2016
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.hindawi.com/journals/omcl/2016/2572606/
Article's DOI: 10.1155/2016/2572606
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: Article number 2572606
Publication Type: Article Artículo Article
Repositori URV