Author, as appears in the article.: M Bullo Bonet; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; J Salas Salvado; M Alemany
Department: Bioquímica i Biotecnologia
URV's Author/s: BULLÓ BONET, MÒNICA; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; SALAS SALVADÓ, JORGE; M Alemany
Keywords: Plasma obese women
Abstract: A group of obese women (BMI>27 kg/m2; N=73) was studied together with lean controls (BMI <27 kg/m2; N=25). Three groups were defined by the compliance with: BMI lower than 27 kg/m2, glycaemia lower than 5.5 mM and insulinaemia lower than 0.2 nM (controls, group 1, N=19). The subjects with BMI>27 kg/m2, glucose >5.5 mM and insulin >0.2 nM constituted group 3 (N=41), and those with BMI>27 with glycaemia and/or insulinaemia lower than the limits set constituted group 2 (N=32). The women in group 3 had higher fat content, BMI and fat-free mass than those in group 2 and the controls. There were no changes in most plasma parameters, such as free estrone and beta-estradiol. Leptin levels were higher in groups 2 and 3 than in controls. In controls, leptin and acyl-estrone levels were well correlated with BMI and fat content; this correlation was not found in groups 2 and 3 for acyl-estrone, although it was found for leptin. Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone. In obese women, acyl-estrone levels -and probably function- are lower than expected, contrasting with maintained leptin-BMI correlations. The role of insulin in the control of body weight, perhaps through acyl estrone-mediated effects, should be re-evaluated.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0743-5800
Author identifier: orcid.org/0000-0002-0218-7046; N/D; N/D; orcid.org/0000-0001-8938-7229; N/D; orcid.org/0000-0003-2700-7459; N/D
Record's date: 2016-06-08
Last page: 476
Journal volume: 26
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2000
First page: 465
Publication Type: Article Artículo Article