Articles producció científica> Bioquímica i Biotecnologia

Cytokine-driven inflammatory response is associated with the hypermetabolism of AIDS patients with opportunistic infections.

  • Identification data

    Identifier: PC:1638
    Handle: https://hdl.handle.net/20.500.11797/PC1638
    Authors:
    Monica Bullo BonetPilar Garcia LordaPilar SerranoMaria Jesus Jimenez-ExpósitoJulia FraileCarlos AlonsoAnna BonadaPompeyo VicianaPedro P Garcia LunaJordi Salas Salvado
    Abstract:
    BACKGROUND: To assess a possible role of systemic inflammation in the resting metabolic response in AIDS patients with active secondary infections. METHODS: Fifty-two patients with AIDS-defined criteria and concomitant active infections and 19 healthy subjects were studied. Measurements were as follows: body composition assessed by bioelectrical impedance; resting energy expenditure (REE) by 30-minute indirect calorimetry; cytokine concentrations (IL-6, IFNalpha, TNFalpha, sTNF-R1) by ELISA; C-reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, and nutritional parameters by standard techniques. RESULTS: REE adjusted for fat-free mass (REEFFM) was significantly increased in AIDS patients despite 39% of them not being hypermetabolic. The patients were undernourished and were found to have increased levels of acute-phase proteins and increased concentrations of IL-6 and sTNF-R1 relative to controls. REE parameters were positively related to CRP, ESR, ferritin, IL-6, and sTNF-R1 and negatively related to albumin, prealbumin, and transferrin. CRP was an independent predictor of REEFFM in AIDS patients and explained 25% of its variability. Patients with severe inflammation (CRP > or = 37 mg/dL) were significantly hypermetabolic with respect to patients without inflammation (CRP < 6 mg/dL) and had higher levels of IL-6 and sTNF-R1 and lower levels of albumin and prealbumin. Although no significant differences were observed with respect to the infection type, patients with tuberculosis and Pneumocystis carinii infections had higher resting metabolic and inflammatory responses, whereas patients with recurrent bacterial pneumonia were normometabolic and had lower levels of inflammatory markers. CONCLUSIONS: Resting hypermetabolism observed in AIDS pat

  • Others:

    Author, as appears in the article.: Monica Bullo Bonet; Pilar Garcia Lorda; Pilar Serrano; Maria Jesus Jimenez-Expósito; Julia Fraile; Carlos Alonso; Anna Bonada; Pompeyo Viciana; Pedro P Garcia Luna ; Jordi Salas Salvado
    Department: Bioquímica i Biotecnologia
    URV's Author/s: BULLÓ BONET, MÒNICA; Pilar Garcia Lorda; Pilar Serrano; Maria Jesus Jimenez-Expósito; Julia Fraile; Carlos Alonso; Anna Bonada; Pompeyo Viciana; Pedro P Garcia Luna ; SALAS SALVADÓ, JORGE
    Keywords: hypermetabolism aids
    Abstract: BACKGROUND: To assess a possible role of systemic inflammation in the resting metabolic response in AIDS patients with active secondary infections. METHODS: Fifty-two patients with AIDS-defined criteria and concomitant active infections and 19 healthy subjects were studied. Measurements were as follows: body composition assessed by bioelectrical impedance; resting energy expenditure (REE) by 30-minute indirect calorimetry; cytokine concentrations (IL-6, IFNalpha, TNFalpha, sTNF-R1) by ELISA; C-reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, and nutritional parameters by standard techniques. RESULTS: REE adjusted for fat-free mass (REEFFM) was significantly increased in AIDS patients despite 39% of them not being hypermetabolic. The patients were undernourished and were found to have increased levels of acute-phase proteins and increased concentrations of IL-6 and sTNF-R1 relative to controls. REE parameters were positively related to CRP, ESR, ferritin, IL-6, and sTNF-R1 and negatively related to albumin, prealbumin, and transferrin. CRP was an independent predictor of REEFFM in AIDS patients and explained 25% of its variability. Patients with severe inflammation (CRP > or = 37 mg/dL) were significantly hypermetabolic with respect to patients without inflammation (CRP < 6 mg/dL) and had higher levels of IL-6 and sTNF-R1 and lower levels of albumin and prealbumin. Although no significant differences were observed with respect to the infection type, patients with tuberculosis and Pneumocystis carinii infections had higher resting metabolic and inflammatory responses, whereas patients with recurrent bacterial pneumonia were normometabolic and had lower levels of inflammatory markers. CONCLUSIONS: Resting hypermetabolism observed in AIDS patients with concurrent active infections is related to the presence and severity of systemic cytokine-driven inflammatory response, which could reflect the type of secondary infection.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0148-6071
    Author identifier: orcid.org/0000-0002-0218-7046; orcid.org/0000-0001-8938-7229; N/D; N/D; N/D; N/D; N/D; N/D; N/D; orcid.org/0000-0003-2700-7459
    Record's date: 2016-06-08
    Last page: 320
    Journal volume: 24
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2000
    First page: 317
    Publication Type: Article Artículo Article

  • Keywords:

    Sida
    Metabolisme energètic
    Citoquines
    hypermetabolism
    aids
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0148-6071

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