Author, as appears in the article.: M Bullo; P Garcia Lorda; R Vilà; M del Mar Grasa; M Alemany; J Salas Salvado
Department: Bioquímica i Biotecnologia
URV's Author/s: BULLÓ BONET, MÒNICA; P Garcia Lorda; R Vilà; M del Mar Grasa; M Alemany; SALAS SALVADÓ, JORGE
Keywords: morbidly obese females Leptin concentrations
Abstract: AIM: To investigate the determinants of leptinemia in a cohort of morbid obese females compared to those of normal weight and mild-to-moderate obesity, and the relationships between leptin and metabolic derangements associated with obesity.
METHODS: Recruited females were: moderately obese [n=44; body mass index (BMI) 25-40 kg/m2], morbidly obese (n=34; BMI > or = 40 kg/m2) and normal weight volunteers (n=12; BMI 19-25 kg/m2). Fat mass assessed by bioelectrical impedance and fat distribution by waist-to-hip ratio (WHR) were determined in all subjects. Biochemical determinations included plasma leptin, lipoprotein profile, fasting insulin and cortisol.
RESULTS: Plasma leptin values were significantly increased in morbid obese patients (54.95 +/- 1.8 ng/ml) compared to those moderately obese (30.2 +/- 1.7 ng/ml; p<0.001) and to controls (9.77 +/- 1.4 ng/ml; p<0.001). Fat and age-adjusted leptin values were not different between groups. When subjects with a BMI <40 kg/m2 were considered, plasma leptin was significantly and positively related to anthropometric variables (BMI, percentage body fat and WHR), total cholesterol, LDL-cholesterol, plasma triglycerides, AST, ALT and uric acid; and negatively with HDL-cholesterol. In contrast, when morbidly obese patients were analyzed separately, no relationships were observed between leptin concentrations and BMI, percentage of adiposity or biochemical variables. For obese patients no significant differences were observed in the adjusted leptin values with respect to the presence of diabetes, dyslipidemia or hypertension.
CONCLUSIONS: In morbidly obese women, the plasma leptin concentrations, although increased, do not reflect the amount of adipose stores, and as such, factors other than simply adiposity need to be invoked to explain the variation in leptin values.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0394-3402
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2016-06-08
Last page: 336
Journal volume: 14
Papper version: info:eu-repo/semantics/publishedVersion
Entity: Universitat Rovira i Virgili
Journal publication year: 2001
First page: 329
Publication Type: Article Artículo Article
Repositori URV