Articles producció científica> Bioquímica i Biotecnologia

Subcutaneous adipose tissue cytokine production is not responsible for the restoration of systemic inflammation markers during weight loss.

  • Identification data

    Identifier: PC:1681
    Authors:
    J Salas-SalvadoM BulloP Garcia-LordaR FigueredoD Del CastilloA BonadaR Balanza
    Abstract:
    CONTEXT: It has been suggested that weight loss can improve systemic inflammation associated with obesity by decreasing the adipose production of pro-inflammatory cytokines. This suggestion, however, remains controversial. OBJECTIVE: To analyse the effect of weight loss on peripheral inflammatory markers and subcutaneous adipocytokine production. DESIGN: Patients were studied at baseline, at the end of the weight loss period, and after 2 weeks of weight stabilisation. SUBJECTS: Nineteen morbid obese non-diabetic patients and 20 lean control subjects. INTERVENTION: During the weight loss period patients followed a 6-week low-calorie diet. MEASUREMENTS: Plasma levels of inflammatory markers, maximal in vitro whole-blood cytokine production, subcutaneous adipose tissue expression and content of several cytokines. RESULTS: Obese subjects had higher circulating levels of C reactive protein (CRP), serum amyloid A (SAA), interleukin IL-6, IL-1 and soluble tumor necrosis factor receptors (sTNFR). Weight loss was associated with a significant decrease in CRP, SAA, leucocytes and plasma IL-6. Maximal in vitro cytokine production of IL-1 and sTNFR1 increased during this period. Weight loss did not induce significant changes in the adipose concentrations of IL-6, IL-1 or sTNF-receptors. However, adipose expression of IL-6, IL-1, TNFalpha, membrane cofactor protein-1 and adiponectin increased at the end of the weight loss period. During weight maintenance, circulating inflammatory parameters increased and in some cases returned to baseline. CONCLUSIONS: A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight sta
  • Others:

    Author, as appears in the article.: J Salas-Salvado; M Bullo; P Garcia-Lorda; R Figueredo; D Del Castillo; A Bonada; R Balanza
    Department: Bioquímica i Biotecnologia
    URV's Author/s: SALAS SALVADÓ, JORGE; BULLÓ BONET, MÒNICA; P Garcia-Lorda; R Figueredo; D Del Castillo; A Bonada; R Balanza
    Keywords: inflammation WEIGHT LOSS cytokine
    Abstract: CONTEXT: It has been suggested that weight loss can improve systemic inflammation associated with obesity by decreasing the adipose production of pro-inflammatory cytokines. This suggestion, however, remains controversial. OBJECTIVE: To analyse the effect of weight loss on peripheral inflammatory markers and subcutaneous adipocytokine production. DESIGN: Patients were studied at baseline, at the end of the weight loss period, and after 2 weeks of weight stabilisation. SUBJECTS: Nineteen morbid obese non-diabetic patients and 20 lean control subjects. INTERVENTION: During the weight loss period patients followed a 6-week low-calorie diet. MEASUREMENTS: Plasma levels of inflammatory markers, maximal in vitro whole-blood cytokine production, subcutaneous adipose tissue expression and content of several cytokines. RESULTS: Obese subjects had higher circulating levels of C reactive protein (CRP), serum amyloid A (SAA), interleukin IL-6, IL-1 and soluble tumor necrosis factor receptors (sTNFR). Weight loss was associated with a significant decrease in CRP, SAA, leucocytes and plasma IL-6. Maximal in vitro cytokine production of IL-1 and sTNFR1 increased during this period. Weight loss did not induce significant changes in the adipose concentrations of IL-6, IL-1 or sTNF-receptors. However, adipose expression of IL-6, IL-1, TNFalpha, membrane cofactor protein-1 and adiponectin increased at the end of the weight loss period. During weight maintenance, circulating inflammatory parameters increased and in some cases returned to baseline. CONCLUSIONS: A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight stabilisation. Furthermore, a negative energy balance and fat mobilisation are associated with increased subcutaneous cytokine adipose expression.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0307-0565
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2016-06-10
    Last page: 1720
    Journal volume: 30
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/0803348
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1038/sj.ijo.0803348
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2006
    First page: 1714
    Publication Type: Article Artículo Article
  • Keywords:

    Citoquines
    Aprimament
    inflammation
    WEIGHT LOSS
    cytokine
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    0307-0565
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