Articles producció científica> Bioquímica i Biotecnologia

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

  • Identification data

    Identifier: PC:1837
    Authors:
    Salas-Salvadó JSmith CEColtell OSorlí JVEstruch RMartínez-González MÁFitó MArós FDashti HSLai CQMiró LSerra-Majem LGómez-Gracia EFiol MRos EAslibekyan SHidalgo BNeuhouser MLDi CTucker KLArnett DKOrdovás JMCorella D
    Abstract:
    Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.
  • Others:

    Author, as appears in the article.: Salas-Salvadó J; Smith CE; Coltell O; Sorlí JV; Estruch R; Martínez-González MÁ; Fitó M; Arós F; Dashti HS; Lai CQ; Miró L; Serra-Majem L; Gómez-Gracia E; Fiol M; Ros E; Aslibekyan S; Hidalgo B; Neuhouser ML; Di C; Tucker KL; Arnett DK; Ordovás JM; Corella D
    Department: Bioquímica i Biotecnologia
    URV's Author/s: SALAS SALVADÓ, JORGE; Smith CE; Coltell O; Sorlí JV; Estruch R; Martínez-González MÁ; Fitó M; Arós F; Dashti HS; Lai CQ; Miró L; Serra-Majem L; Gómez-Gracia E; Fiol M; Ros E; Aslibekyan S; Hidalgo B; Neuhouser ML; Di C; Tucker KL; Arnett DK; Ordovás JM; Corella D
    Keywords: MCM6-rs3754686 cardiovascular biomarkers Mortality
    Abstract: Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2045-2322
    Record's date: 2016-09-16
    Last page: 33188
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/srep33188
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: https://doi.org/10.1038/srep33188
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 33188
    Publication Type: Article Artículo Article
  • Keywords:

    Marcadors bioquímics
    Sistema cardiovascular malalties
    Mortalitat
    MCM6-rs3754686
    cardiovascular biomarkers
    Mortality
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    2045-2322
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