Author, as appears in the article.: Salas-Salvado J; Zheng Y; Hu FB; Ruiz-Canela M; Clish CB; Dennis C; Hruby A; Liang L; Toledo E; Corella D; Ros E; Fitó M; Gómez-Gracia E; Arós F; Fiol M; Lapetra J; Serra-Majem L; Estruch R; Martínez-González MA
Department: Bioquímica i Biotecnologia
URV's Author/s: SALAS SALVADÓ, JORGE; Zheng Y; Hu FB; Ruiz-Canela M; Clish CB; Dennis C; Hruby A; Liang L; Toledo E; Corella D; Ros E; Fitó M; Gómez-Gracia E; Arós F; Fiol M; Lapetra J; Serra-Majem L; Estruch R; Martínez-González MA
Keywords: Glutamate Metabolism Cardiovascular Events PREDIMED
Abstract: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD).
METHODS AND RESULTS:
Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent.
CONCLUSIONS:
Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2047-9980
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2016-09-19
Journal volume: 5
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.ahajournals.org/doi/full/10.1161/JAHA.116.003755?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1161/JAHA.116.003755
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Article Artículo Article
Repositori URV