Articles producció científica> Medicina i Cirurgia

Switching antiretroviral regimes for the treatment of HIV: safety implications

  • Identification data

    Identifier: PC:1853
    Authors:
    Francesc VidalLaia UtrilloTeresa PuigPere Domingo
    Abstract:
    DOI: 10.1080/14740338.2016.1206076 URL: http://www.tandfonline.com/doi/full/10.1080/14740338.2016.1206076 Filiació URV: SI
  • Others:

    Author, as appears in the article.: Francesc Vidal; Laia Utrillo; Teresa Puig; Pere Domingo
    Department: Medicina i Cirurgia
    URV's Author/s: VIDAL MARSAL, FRANCISCO; Laia Utrillo; Teresa Puig; Pere Domingo
    Keywords: toxicity
    Abstract: Introduction: There are multiple reasons to switch from a virologically successful antiretroviral regimen. Some of them are related to toxicity. Lately, combination antiretroviral treatment (cART) switches have often been related to drug-drug interactions which may also eventually entail safety issues as well. Areas covered: The purpose of this review is to analyze causes of switching between virologically successful cART regimes related to safety issues. The most relevant papers were selected and summarized. Expert opinion: Switching cART has been a popular strategy to address safety issues throughout the antiretroviral era. The myriad of switching studies have paralleled the study and release into clinical practice of new antiretroviral drugs with different and often improved safety profiles. Most of them have been successful in improving antiretroviral toxicity while keeping HIV replication under control. However, it should be taken into account that, whenever a new drug is given, there is a possibility of new drug-related toxicity. Notwithstanding that, an increase in cART switching is foreseen, given the fact that we have a wide antiretroviral drug armamentarium and that people living with HIV are ageing and thus more prone to developing age-related co-morbidities whose therapies may entail new interactions and eventually new toxicities.
    Research group: Grup de Recerca Biomèdica HJ23
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1474-0338
    Author identifier: N/D; N/D; N/D; N/D
    Record's date: 2016-10-10
    Last page: 1360
    Journal volume: 15
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.tandfonline.com/doi/full/10.1080/14740338.2016.1206076
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1080/14740338.2016.1206076
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 1349
    Publication Type: Article Artículo Article
  • Keywords:

    Toxicitat
    VIH (Virus)
    toxicity
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1474-0338
  • Documents:

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