Articles producció científicaEnginyeria Informàtica i Matemàtiques

Mapping multiplex hubs in human functional brain networks

  • Identification data

    Identifier:  PC:1904
    Authors:  Manlio de Domenico; Shuntaro Sasai; Alex Arenas
    Abstract:
    Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar architectures with unique profiles of region centrality. However, the identification of hubs in networks built from different frequency bands simultaneously is still a challenging problem, remaining largely unexplored. Here we identify each frequency component with one layer of a multiplex network and face this challenge by exploiting the recent advances in the analysis of multiplex topologies. First, we show that each frequency band carries unique topological information, fundamental to accurately model brain functional networks. We then demonstrate that hubs in the multiplex network, in general different from those ones obtained after discarding or aggregating the measured signals as usual, provide a more accurate map of brain's most important functional regions, allowing to distinguish between healthy and schizophrenic populations better than conventional network approaches.
  • Others:

    Link to the original source: http://journal.frontiersin.org/article/10.3389/fnins.2016.00326/full
    Article's DOI: 10.3389/fnins.2016.00326
    Journal publication year: 2016
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2016-09-21
    First page: Art. num. 326
    URV's Author/s: DE DOMENICO ., MANLIO; Shuntaro Sasai; ARENAS MORENO, ALEJANDRO
    Department: Enginyeria Informàtica i Matemàtiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Article
    ISSN: 1662-453X
    Author, as appears in the article.: Manlio de Domenico; Shuntaro Sasai; Alex Arenas
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 10
    Research group: Algorithms embedded in Physical Systems
    Thematic Areas: Computer engineering
  • Keywords:

    Brain fMRI
    schizophrenia
    Multiplex hubs
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