Author, as appears in the article.: Maria Teresa Colomina; Pia Basaure; Fiona Peris-Sampedro; Maria Cabré; Ingrid Reverte
Department: Psicologia
URV's Author/s: COLOMINA FOSCH, MARIA TERESA; Pia Basaure; Fiona Peris-Sampedro; Maria Cabré; Ingrid Reverte
Keywords: Cholinesterase inhibitor Rivastigmine chlorpyrifos
Abstract: Cholinesterases (ChE) are common targets of organophosphate (OP) pesticides and play a critical role in the pathology of some dementias. While chlorpyrifos (CPF) remains one of the most commonly used OPs in the world, numerous investigations have reported its neurotoxic potential and highlighted behavioral disturbances upon its administration. Rivastigmine currently serves to treat Alzheimer's disease, but it may induce cholinergic overstimulation in non-demented individuals. The present investigation aimed to compare the acute and delayed effects caused by both ChE inhibitors in adult C57BL/6 male mice. The animals were daily fed either a standard, a CPF- (5 mg/kg body weight) or a rivastigmine-supplemented diet (1 or 2 mg/kg body weight) for 8 weeks. After the treatment, we established an 8-week washout period to assess recovery. ChE enzyme activity, biomarkers, physical effects, and behavioral alterations were evaluated at different time points during the exposure and after the washout period. Both rivastigmine doses induced a time-dependent weight increase. CPF and rivastigmine inhibited brain acetylcholinesterase following an isoform-specific pattern. As for behavioral assessment, CPF negatively modulated learning strategies and impaired memory in a Barnes maze task at the end of the exposure. On the other hand, the low dose of rivastigmine improved memory recall at the end of the washout period in a Morris water maze. Indeed, our results endorse the positive effects of low doses of rivastigmine following a drug-free period in young mice. Therefore, doses and periodicity of treatment to improve cognition in elderly people upon rivastigmine administration should be revised.
Research group: Recerca en Neurocomportament i salut
Thematic Areas: Psychology Psicología Psicologia
ISSN: 0166-4328
Author identifier: 0000-0002-5619-4874; n/a; 0000-0002-6747-429X; 0000-0003-4124-8603; 0000-0002-4120-9324
Record's date: 2016-11-24
Last page: 11
Journal volume: 318
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0166432816307938?via%3Dihub
Article's DOI: 10.1016/j.bbr.2016.10.014
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
First page: 1
Publication Type: Article Artículo Article
Repositori URV