Articles producció científica> Bioquímica i Biotecnologia

Mercury exposure and risk of cardiovascular disease: A nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

  • Identification data

    Identifier: PC:2487
    Authors:
    Jordi Salas-SalvadóMary K. DownerMiguel A. Martínez-GonzálezAlfredo GeaMeir StampferJulia WarnbergMiguel Ruiz-CanelaDolores CorellaEmilio RosMontse FitóRamon EstruchFernando ArósMiquel FiolJosé LapetraLluís Serra-MajemMonica BulloJose V. SorliMiguel A. MuñozAntonio García-RodriguezMario Gutierrez-BedmarEnrique Gómez-Gracia
    Abstract:
    DOI: 10.1186/s12872-016-0435-8 URL: http://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-016-0435-8 Filiació URV: SI Inclòs a la memòria: SI
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    Author, as appears in the article.: Jordi Salas-Salvadó; Mary K. Downer; Miguel A. Martínez-González; Alfredo Gea; Meir Stampfer; Julia Warnberg; Miguel Ruiz-Canela; Dolores Corella; Emilio Ros; Montse Fitó; Ramon Estruch; Fernando Arós; Miquel Fiol; José Lapetra; Lluís Serra-Majem; Monica Bullo; Jose V. Sorli; Miguel A. Muñoz; Antonio García-Rodriguez; Mario Gutierrez-Bedmar; Enrique Gómez-Gracia
    Department: Bioquímica i Biotecnologia
    URV's Author/s: SALAS SALVADÓ, JORGE; Mary K. Downer; Miguel A. Martínez-González; Alfredo Gea; Meir Stampfer; Julia Warnberg; Miguel Ruiz-Canela; Dolores Corella; Emilio Ros; Montse Fitó; Ramon Estruch; Fernando Arós; Miquel Fiol; José Lapetra; Lluís Serra-Majem; Monica Bullo; Jose V. Sorli; Miguel A. Muñoz; Antonio García-Rodriguez; Mario Gutierrez-Bedmar; Enrique Gómez-Gracia
    Keywords: Mediterranean diet Fish cardiovascular disease
    Abstract: Background: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail mercury concentration. In-person interviews, medical record reviews and validated questionnaires were used to assess fish consumption and other covariates. Information was collected at baseline and updated yearly during follow-up. We used conditional logistic regression to evaluate associations in the total nested case-control study, and unconditional logistic regression for population subsets. Results: Mean (±SD) toenail mercury concentrations (μg per gram) did not significantly differ between cases (0.63 (±0.53)) and controls (0.67 (±0.49)). Mercury concentration was not associated with cardiovascular disease in any analysis, and neither was fish consumption or n-3 fatty acids. The fully-adjusted relative risks for the highest versus lowest quartile of mercury concentration were 0.71 (95% Confidence Interval [CI], 0.34, 1.14; ptrend=0.37) for the nested case-control study, 0.74 (95% CI, 0.32, 1.76; ptrend=.43) within the Mediterranean diet intervention group, and 0.50 (95% CI, 0.13, 1.96; ptrend=0.41) within the control arm of the trial. Associations remained null when mercury was jointly assessed with fish consumption at baseline and during follow-up. Results were similar in different sensitivity analyses. Conclusions: We found no evidence that mercury exposure from regular fish consumption increases cardiovascular disease risk in a population of Spanish adults with high cardiovascular disease risk and high fish consumption. This implies that the mercury content in fish does not detract from the already established cardiovascular benefits of fish consumption.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471-2261
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2017-01-19
    Journal volume: 17
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-016-0435-8
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1186/s12872-016-0435-8
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: Art.num. 9
    Publication Type: Article Artículo Article
  • Keywords:

    Dieta mediterrània
    Mercuri -- Toxicologia
    Sistema cardiovascular malalties
    Mediterranean diet
    Fish
    cardiovascular disease
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    1471-2261
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