Author, as appears in the article.: Oscar Pàmies; Jèssica Margalef; Montserrat Diéguez
Department: Química Física i Inorgànica
URV's Author/s: PAMIES OLLÉ, OSCAR; Jèssica Margalef; DIÉGUEZ FERNÁNDEZ, MONTSERRAT
Keywords: asymmetric transfer hydrogenation ketones sugar-based ligands
Abstract: Asymmetric transfer hydrogenation (ATH) has emerged as one of the most effective and sustainable synthetic
tool for synthesizing enantiopure alcohols. Since Noyori’s group successfully applied Ru-catalysts
modified with chiral b-amino alcohols or diamines as ligands, a large number of catalytic systems has
been successfully developed. However, further improvement in terms of substrate scope, selectivity,
and turnover frequency are required to make the process competitive with conventional hydrogenations.
Overcoming these limitations requires research toward the design of new ligands. Such a task becomes
easier if readily modulable chiral ligands are at hand. Sugar-based ligands are particularly useful for
addressing this need. They are readily available, highly functionalized, and their modular constructions
are easy. Series of chiral ligands can be screened in the search for high activities and selectivities for each
type of substrate. This digest paper will discuss the progress on the use of sugar-based ligands in ATH
reactions.
Research group: Organometàl.lics i Catàlisi Homogènia
Thematic Areas: Química Química Chemistry
licence for use: thttps://creativecommons.org/licenses/by/3.0/es/
ISSN: 0040-4039
Author identifier: 0000-0002-2352-8508; n/a; 0000-0002-8450-0656
Record's date: 2017-02-22
Last page: 1308
Journal volume: 57
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0040403916301320
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: https://doi.org/10.1016/j.tetlet.2016.02.022
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 1301
Publication Type: Post-print
Repositori URV