Articles producció científica> Bioquímica i Biotecnologia

New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9

  • Identification data

    Identifier: PC:2595
    Authors:
    Sánchez-López E, Ettcheto M, Egea MA, Espina M, Calpena AC, Folch J, Camins A, García ML.
    Abstract:
    DOI: 10.1016/j.nano.2016.12.003 URL: http://www.sciencedirect.com/science/article/pii/S1549963416302209 Filiació URV: SI Memòria
  • Others:

    Author, as appears in the article.: Sánchez-López E, Ettcheto M, Egea MA, Espina M, Calpena AC, Folch J, Camins A, García ML.
    Department: Bioquímica i Biotecnologia
    URV's Author/s: FOLCH LOPEZ, JAUME
    Keywords: nanoparticles Alzheimer's disease
    Abstract: Dexibuprofen loaded pegylated poly(lactic-co-glycolic) nanospheres prepared by solvent diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic side effects. Nanospheres exhibited a mean particle size around 200 nm (195.4 nm), monomodal population and negative surface charge. Drug loaded nanospheres showed a sustained release profile, allowing to modify the posology in vivo. Nanospheres were non-toxic neither in brain endothelial cells nor astrocytes and do not cause blood–brain barrier disruption. Nanospheres were able to partially cross the cells barrier and release the drug after co-culture in vitro experiments, increasing Dexibuprofen permeation coefficient. Behavioral tests performed in APPswe/PS1dE9 mice (mice model of familial Alzheimer's disease) showed that nanospheres reduce memory impairment more efficiently than the free drug. Developed nanospheres decrease brain inflammation leading to β-amyloid plaques reduction. According to these results, chronical oral Dexibuprofen pegylated poly(lactic-co-glycolic) nanosystems could constitute a suitable strategy for the prevention of neurodegeneration.
    Research group: Farmacobiologia Cel.lular
    Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1549-9634
    Record's date: 2017-03-07
    Last page: 1182
    Journal volume: 13
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1549963416302209
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.nano.2016.12.003
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: 1171
    Publication Type: Article Artículo Article
  • Keywords:

    Nanopartícules
    Alzheimer, Malaltia d' -- Prevenció
    nanoparticles
    Alzheimer's disease
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    1549-9634
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