Author, as appears in the article.: Bardají, A.; Leal, M.; Arrarte, V.; Garcia-Moll, X.; Pérez de Isla, L.; Bueno, H.
Department: Medicina i Cirurgia
URV's Author/s: BARDAJÍ RUIZ, ALFREDO; Leal, M.; Arrarte, V.; Garcia-Moll, X.; Pérez de Isla, L.; Bueno, H.
Keywords: Coronary artery disease Acute coronary syndrome myocardial infarction
Abstract: Introduction: Real-world, country-specific studies of dual antiplatelet therapy (DAPT) duration among survivors of acute coronary syndrome (ACS) are important for improving long-term prognosis. Aims: To investigate DAPT duration after hospital discharge for ACS in Spain. Results: Data from patients enrolled in the Spanish cohort of the EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) study (NCT01171404) were analyzed for changes to antithrombotic medication up to 2 years postdischarge according to index event diagnosis and patient characteristics. Deaths, coronary events, and bleeding events were analyzed over the same period. Overall, a high proportion of patients remained on DAPT at 2 years (53.1%). Among patients who experienced any on-treatment bleeding event, almost two-thirds remained on DAPT at the end of follow-up. Patients >65 years, diabetic, or those that were medically managed were more likely to continue with DAPT until 2 years following discharge. At 2 years, the incidence of bleeding events requiring hospitalization was low compared with the incidence of coronary events (1.4% vs 6.6%). There was a numerical reduction in coronary events, but no increase in bleeding events, with DAPT continuation compared with single antiplatelet therapy. Conclusions: More than half of patients in this unselected cohort study remained on DAPT at 2 years following discharge for ACS. Continuation with DAPT was greater among patients with additional cardiovascular risk factors, which suggests that treating physicians in Spain prioritizes ischemic risk reduction over bleeding risk in patients with ACS, according to patient's risk profile.
Research group: Grup de Recerca Biomèdica HJ23
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1755-5914
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2017-03-28
Journal volume: 35
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/1755-5922.12237
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1111/1755-5922.12237
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
First page: Art.num. e12237
Publication Type: Article Artículo Article
Repositori URV