Articles producció científica> Ciències Mèdiques Bàsiques

Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats

  • Identification data

    Identifier: PC:2631
    Authors:
    Molinar-Toribio, E.Ramos-Romero, S.Fuguet, E.Taltavull, N.Méndez, L.Romeu, M.Medina, I.Torres, J.L.Pérez-Jiménez, J.
    Abstract:
    Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18 weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16.6 g/kg feed), proanthocyanidin-rich grape seed extract (0.8 g/kg feed) or both. A total of 39 microbial-derived metabolites and 16 conjugated metabolites were detected by HPLC-MS/MS either in urine or in the aqueous fraction of feces. An unexpected significant increase in many proanthocyanidin metabolites in urine and feces was observed in the group supplemented with ω-3 polyunsaturated fatty acids group as compared to the animals fed a standard diet, which contains a small amount of polyphenols. However, proanthocyanidin metabolites in rats given ω-3 polyunsaturated fatty acids and grape seed extract did not significantly differ from those in the group supplemented only with grape seed extract. It was concluded that ω-3 polyunsaturated fatty acids collaborate in the metabolism of polyphenols when present at low doses in the feed matrix, while the capacity of ω-3 polyunsaturated fatty acids to induce microbiota transformations when proanthocyanidins are present at high doses is not relevant compared to that of polyphenols themselves.
  • Others:

    Author, as appears in the article.: Molinar-Toribio, E.; Ramos-Romero, S.; Fuguet, E.; Taltavull, N.; Méndez, L.; Romeu, M.; Medina, I.; Torres, J.L.; Pérez-Jiménez, J.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: TALTAVULL ANGLADA, NÚRIA; ROMEU FERRAN, MARTA
    Keywords: Bioavailability Polyphenols Proanthocyanidins
    Abstract: Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18 weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16.6 g/kg feed), proanthocyanidin-rich grape seed extract (0.8 g/kg feed) or both. A total of 39 microbial-derived metabolites and 16 conjugated metabolites were detected by HPLC-MS/MS either in urine or in the aqueous fraction of feces. An unexpected significant increase in many proanthocyanidin metabolites in urine and feces was observed in the group supplemented with ω-3 polyunsaturated fatty acids group as compared to the animals fed a standard diet, which contains a small amount of polyphenols. However, proanthocyanidin metabolites in rats given ω-3 polyunsaturated fatty acids and grape seed extract did not significantly differ from those in the group supplemented only with grape seed extract. It was concluded that ω-3 polyunsaturated fatty acids collaborate in the metabolism of polyphenols when present at low doses in the feed matrix, while the capacity of ω-3 polyunsaturated fatty acids to induce microbiota transformations when proanthocyanidins are present at high doses is not relevant compared to that of polyphenols themselves.
    Research group: Farmacobiologia Cel.lular
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0963-9969
    Record's date: 2017-04-26
    Last page: 140
    Journal volume: 97
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0963996917301400?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.foodres.2017.03.046
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: 133
    Publication Type: Article Artículo Article
  • Keywords:

    Polifenols
    Proantocianidines
    Biodisponibilitat
    Bioavailability
    Polyphenols
    Proanthocyanidins
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    0963-9969
  • Documents:

  • Cerca a google

    Search to google scholar