Author, as appears in the article.: Mas, A.; González, B.; Beltran, G.; Cullen, P.J.; Torija, M.J.
Department: Bioquímica i Biotecnologia
URV's Author/s: MAS BARON, ALBERTO; González, B.; BELTRAN CASELLAS, GEMMA; Cullen, P.J.; TORIJA MARTÍNEZ, MARÍA JESÚS
Keywords: filamentous growth pseudohyphal growth quorum sensing
Abstract: In yeast, ethanol is produced as a by-product of fermentation through glycolysis. Ethanol also stimulates a developmental foraging response called filamentous growth and is thought to act as a quorum-sensing molecule. Ethanol-inducible filamentous growth was examined in a small collection of wine/European strains, which validated ethanol as an inducer of filamentous growth. Wine strains also showed variability in their filamentation responses, which illustrates the striking phenotypic differences that can occur among individuals. Ethanol-inducible filamentous growth in 61278b strains was independent of several of the major filamentation regulatory pathways [including fMAPK, RAS-cAMP, Snf1, Rpd3(L), and Rim101] but required the mitochondrial retrograde (RTG) pathway, an inter-organellar signaling pathway that controls the nuclear response to defects in mitochondrial function. The RTG pathway regulated ethanol-dependent filamentous growth by maintaining flux through the TCA cycle. The ethanol-dependent invasive growth response required the polarisome and transcriptional induction of the cell adhesion molecule Flo11p. Our results validate established stimuli that trigger filamentous growth and show how stimuli can trigger highly specific responses among individuals. Our results also connect an inter-organellar pathway to a quorum sensing response in fungi.
Research group: Biotecnologia Enològica
Thematic Areas: Enologia Enología Oenology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1664-042X
Author identifier: 0000-0002-0763-1679; n/a; 0000-0002-7071-205X; n/a; 0000-0001-6419-0745
Record's date: 2017-05-18
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: http://journal.frontiersin.org/article/10.3389/fphys.2017.00148/full
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3389/fphys.2017.00148
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
First page: Art.num. 148
Publication Type: Article Artículo Article