Author, as appears in the article.: Becerra-Tomás, N.; Díaz-López, A.; Rosique-Esteban, N.; Ros, E.; Buil-Cosiales, P.; Corella, D.; Estruch, R.; Fitó, M.; Serra-Majem, L.; Arós, F.; Lamuela-Reventós, RM.; Fiol, M.; Santos-Lozano, JM.; Díez-Espino, J.; Portoles, O.; Salas-Salvadó, J.; Babio, N.
Department: Bioquímica i Biotecnologia
URV's Author/s: BECERRA TOMÁS, NEREA; Díaz-López, A.; Rosique-Esteban, N.; Ros, E.; Buil-Cosiales, P.; Corella, D.; Estruch, R.; Fitó, M.; Serra-Majem, L.; Arós, F.; Lamuela-Reventós, RM.; Fiol, M.; Santos-Lozano, JM.; Díez-Espino, J.; Portoles, O.; SALAS SALVADÓ, JORGE; BABIO SÁNCHEZ, NANCY ELVIRA
Keywords: PREDIMED study Type-2 diabetes
Abstract: BACKGROUND & AIMS:
Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods.
METHODS:
Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas.
RESULTS:
During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46-0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence.
CONCLUSIONS:
A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk.
Research group: Alimentació, Nutrició, Creixement i Salut Mental
Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0261-5614
Author identifier: 0000-0002-4429-6507; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 0000-0003-2700-7459; 0000-0003-3527-5277
Record's date: 2018-06-25
Last page: 913
Journal volume: 37
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://linkinghub.elsevier.com/retrieve/pii/S0261561417301061
Article's DOI: 10.1016/j.clnu.2017.03.015
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
First page: 906
Publication Type: Article Artículo Article
Repositori URV