Articles producció científica> Bioquímica i Biotecnologia

Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

  • Identification data

    Identifier: PC:3366
    Authors:
    Becerra-Tomás, N.Díaz-López, A.Rosique-Esteban, N.Ros, E.Buil-Cosiales, P.Corella, D.Estruch, R.Fitó, M.Serra-Majem, L.Arós, F.Lamuela-Reventós, RM.Fiol, M.Santos-Lozano, JM.Díez-Espino, J.Portoles, O.Salas-Salvadó, J.Babio, N.
    Abstract:
    BACKGROUND & AIMS: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. METHODS: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. RESULTS: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46-0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. CONCLUSIONS: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean die
  • Others:

    Author, as appears in the article.: Becerra-Tomás, N.; Díaz-López, A.; Rosique-Esteban, N.; Ros, E.; Buil-Cosiales, P.; Corella, D.; Estruch, R.; Fitó, M.; Serra-Majem, L.; Arós, F.; Lamuela-Reventós, RM.; Fiol, M.; Santos-Lozano, JM.; Díez-Espino, J.; Portoles, O.; Salas-Salvadó, J.; Babio, N.
    Department: Bioquímica i Biotecnologia
    URV's Author/s: BECERRA TOMÁS, NEREA; Díaz-López, A.; Rosique-Esteban, N.; Ros, E.; Buil-Cosiales, P.; Corella, D.; Estruch, R.; Fitó, M.; Serra-Majem, L.; Arós, F.; Lamuela-Reventós, RM.; Fiol, M.; Santos-Lozano, JM.; Díez-Espino, J.; Portoles, O.; SALAS SALVADÓ, JORGE; BABIO SÁNCHEZ, NANCY ELVIRA
    Keywords: PREDIMED study Type-2 diabetes
    Abstract: BACKGROUND & AIMS: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. METHODS: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. RESULTS: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46-0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. CONCLUSIONS: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0261-5614
    Author identifier: 0000-0002-4429-6507; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 0000-0003-2700-7459; 0000-0003-3527-5277
    Record's date: 2018-06-25
    Last page: 913
    Journal volume: 37
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://linkinghub.elsevier.com/retrieve/pii/S0261561417301061
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.clnu.2017.03.015
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    First page: 906
    Publication Type: Article Artículo Article
  • Keywords:

    Dieta mediterrània
    Diabetis
    PREDIMED study
    Type-2 diabetes
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0261-5614
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