Articles producció científica> Bioquímica i Biotecnologia

Grape-seed procyanidins prevent the cafeteria-diet-induced decrease of glucagon-like peptide-1 production

  • Identification data

    Identifier: PC:642
    Handle: http://hdl.handle.net/20.500.11797/PC642

  • Authors:

    Pinent, M.
    Ardèvol, A.
    Blay, M.
    Martínez, N.
    González, N.

  • Others:

    Author, as appears in the article.: Pinent, M. Ardèvol, A. Blay, M. Martínez, N. González, N.
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: http://pubs.acs.org/doi/pdf/10.1021/jf405239p
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Noemi González-Abuín; Neus Martínez-Micaelo; Mayte Blay; Anna Ardévol; Montserrat Pinent
    Abstract: Grape-seed procyanidin extract (GSPE) has been reported to improve insulin resistance in cafeteria rats. Because glucagon-like peptide-1 (GLP-1) is involved in glucose homeostasis, the preventive effects of GSPE on GLP-1 production, secretion, and elimination were evaluated in a model of diet-induced insulin resistance. Rats were fed a cafeteria diet for 12 weeks, and 25 mg of GSPE/kg of body weight was administered concomitantly. Vehicle-treated cafeteria-fed rats and chow-fed rats were used as controls. The cafeteria diet decreased active GLP-1 plasma levels, which is attributed to a decreased intestinal GLP-1 production, linked to reduced colonic enteroendocrine cell populations. Such effects were prevented by GSPE. In the same context, GSPE avoided the decrease on intestinal dipeptidyl-peptidase 4 (DPP4) activity and modulated the gene expression of GLP-1 and its receptor in the hypothalamus. In conclusion, the preventive treatment with GSPE abrogates the effects of the cafeteria diet on intestinal GLP-1 production and DPP4 activity.
    Entity: Universitat Rovira i Virgili.
    Journal publication year: 2014
    First page: 1066
    Last page: 1072
    Journal volume: 62