Author, as appears in the article.: Martinez-Gonzalez, Miguel A.; Zazpe, Itziar; Razquin, Cristina; Sanchez-Tainta, Ana; Corella, Dolores; Salas-Salvado, Jordi; Toledo, Estefania; Ros, Emilio; Angel Munoz, Miguel; Recondo, Javier; Gomez-Gracia, Enrique; Fiol, Miguel; Lapetra, Jose; Buil-Cosiales, Pilar; Serra-Majem, Lluis; Pinto, Xavier; Schroeder, Helmut; Tur, Josep A.; Sorli, Jose V.; Lamuela-Raventos, Rosa M.; Estruch, Ramon;PREDIMED GRP
Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
Keywords: Women Survival Spanish men Questionnaire Prospective cohort Predimed study Predimed Olive oil Mortality Mediterranean diet Disease Dietary patterns Dietary pattern Cardiovascular risk Adherence mortality mediterranean diet dietary pattern cardiovascular risk
Abstract: There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association between a posteriori defined baseline major DP and total mortality or cardiovascular events within each of the three arms of a large primary prevention trial (PREDIMED) where participants were randomized to two active interventions with Mediterranean-type diets or to a control group (allocated to a low-fat diet).We followed-up 7216 participants for a median of 4.3 years. A validated 137-item food-frequency questionnaire was administered. Baseline DP were ascertained through factor analysis based on 34 predefined groups. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for cardiovascular disease (CVD) or mortality across quartiles of DP within each of the three arms of the trial.We identified two major baseline DP: the first DP was rich in red and processed meats, alcohol, refined grains and whole dairy products and was labeled Western dietary pattern (WDP). The second DP corresponded to a "Mediterranean-type" dietary pattern (MDP). During follow-up, 328 participants died. After controlling for potential confounders, higher baseline adherence to the MDP was associated with lower risk of CVD (adjusted HR for fourth vs. first quartile: 0.52; 95% CI (Confidence Interval): 0.36, 0.74; p-trend <0.001) and all-cause mortality (adjusted HR: 0.53; 95% CI: 0.38, 0.75; p-trend <0.001), regardless of the allocated arm of the trial. An increasing mortality rate was found across increasing quartiles of the WDP in the control group (allocated to a low-fat diet), though the linear trend was not statistically significant (p = 0.098).Higher adherence to an empirically-derived MDP at baseline was associated with a reduced risk of CVD and mortality in the PREDIMED trial regardless of the allocated arm. The WDP was not associated with higher risk of mortality or cardiovascular events.Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02615614
Author's mail: juanjose.cabre@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-1082-6861 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Nutrition. 34 (5): 859-867
APA: Martinez-Gonzalez, Miguel A.; Zazpe, Itziar; Razquin, Cristina; Sanchez-Tainta, Ana; Corella, Dolores; Salas-Salvado, Jordi; Toledo, Estefania; Ros, E (2015). Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study. Clinical Nutrition, 34(5), 859-867. DOI: 10.1016/j.clnu.2014.09.006
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV