Articles producció científica> Medicina i Cirurgia

Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study

  • Identification data

    Identifier: imarina:1968269
    Authors:
    Martinez-Gonzalez, Miguel A.Zazpe, ItziarRazquin, CristinaSanchez-Tainta, AnaCorella, DoloresSalas-Salvado, JordiToledo, EstefaniaRos, EmilioAngel Munoz, MiguelRecondo, JavierGomez-Gracia, EnriqueFiol, MiguelLapetra, JoseBuil-Cosiales, PilarSerra-Majem, LluisPinto, XavierSchroeder, HelmutTur, Josep A.Sorli, Jose V.Lamuela-Raventos, Rosa M.Estruch, RamonPREDIMED GRP
    Abstract:
    There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association between a posteriori defined baseline major DP and total mortality or cardiovascular events within each of the three arms of a large primary prevention trial (PREDIMED) where participants were randomized to two active interventions with Mediterranean-type diets or to a control group (allocated to a low-fat diet).We followed-up 7216 participants for a median of 4.3 years. A validated 137-item food-frequency questionnaire was administered. Baseline DP were ascertained through factor analysis based on 34 predefined groups. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for cardiovascular disease (CVD) or mortality across quartiles of DP within each of the three arms of the trial.We identified two major baseline DP: the first DP was rich in red and processed meats, alcohol, refined grains and whole dairy products and was labeled Western dietary pattern (WDP). The second DP corresponded to a "Mediterranean-type" dietary pattern (MDP). During follow-up, 328 participants died. After controlling for potential confounders, higher baseline adherence to the MDP was associated with lower risk of CVD (adjusted HR for fourth vs. first quartile: 0.52; 95% CI (Confidence Interval): 0.36, 0.74; p-trend <0.001) and all-cause mortality (adjusted HR: 0.53; 95% CI: 0.38, 0.75; p-trend <0.001), regardless of the allocated arm of the trial. An increasing mortality rate was found across increasing quartiles of the WDP in the control group (allocated to a low-fat diet), though the linear
  • Others:

    Author, as appears in the article.: Martinez-Gonzalez, Miguel A.; Zazpe, Itziar; Razquin, Cristina; Sanchez-Tainta, Ana; Corella, Dolores; Salas-Salvado, Jordi; Toledo, Estefania; Ros, Emilio; Angel Munoz, Miguel; Recondo, Javier; Gomez-Gracia, Enrique; Fiol, Miguel; Lapetra, Jose; Buil-Cosiales, Pilar; Serra-Majem, Lluis; Pinto, Xavier; Schroeder, Helmut; Tur, Josep A.; Sorli, Jose V.; Lamuela-Raventos, Rosa M.; Estruch, Ramon;PREDIMED GRP
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
    Keywords: Women Survival Spanish men Questionnaire Prospective cohort Predimed study Predimed Olive oil Mortality Mediterranean diet Disease Dietary patterns Dietary pattern Cardiovascular risk Adherence mortality mediterranean diet dietary pattern cardiovascular risk
    Abstract: There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association between a posteriori defined baseline major DP and total mortality or cardiovascular events within each of the three arms of a large primary prevention trial (PREDIMED) where participants were randomized to two active interventions with Mediterranean-type diets or to a control group (allocated to a low-fat diet).We followed-up 7216 participants for a median of 4.3 years. A validated 137-item food-frequency questionnaire was administered. Baseline DP were ascertained through factor analysis based on 34 predefined groups. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for cardiovascular disease (CVD) or mortality across quartiles of DP within each of the three arms of the trial.We identified two major baseline DP: the first DP was rich in red and processed meats, alcohol, refined grains and whole dairy products and was labeled Western dietary pattern (WDP). The second DP corresponded to a "Mediterranean-type" dietary pattern (MDP). During follow-up, 328 participants died. After controlling for potential confounders, higher baseline adherence to the MDP was associated with lower risk of CVD (adjusted HR for fourth vs. first quartile: 0.52; 95% CI (Confidence Interval): 0.36, 0.74; p-trend <0.001) and all-cause mortality (adjusted HR: 0.53; 95% CI: 0.38, 0.75; p-trend <0.001), regardless of the allocated arm of the trial. An increasing mortality rate was found across increasing quartiles of the WDP in the control group (allocated to a low-fat diet), though the linear trend was not statistically significant (p = 0.098).Higher adherence to an empirically-derived MDP at baseline was associated with a reduced risk of CVD and mortality in the PREDIMED trial regardless of the allocated arm. The WDP was not associated with higher risk of mortality or cardiovascular events.Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02615614
    Author's mail: juanjose.cabre@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-1082-6861 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(14)00233-7/abstract
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 34 (5): 859-867
    APA: Martinez-Gonzalez, Miguel A.; Zazpe, Itziar; Razquin, Cristina; Sanchez-Tainta, Ana; Corella, Dolores; Salas-Salvado, Jordi; Toledo, Estefania; Ros, E (2015). Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study. Clinical Nutrition, 34(5), 859-867. DOI: 10.1016/j.clnu.2014.09.006
    Article's DOI: 10.1016/j.clnu.2014.09.006
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Women
    Survival
    Spanish men
    Questionnaire
    Prospective cohort
    Predimed study
    Predimed
    Olive oil
    Mortality
    Mediterranean diet
    Disease
    Dietary patterns
    Dietary pattern
    Cardiovascular risk
    Adherence
    mortality
    mediterranean diet
    dietary pattern
    cardiovascular risk
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar