Author, as appears in the article.: Fernandez-Cao, Jose C; Arija, Victoria; Aranda, Nuria; Basora, Josep; Diez-Espino, Javier; Estruch, Ramon; Fito, Montse; Corella, Dolores; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Medicina i Cirurgia Ciències Mèdiques Bàsiques
URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Fernández Sáez, José / Salas Salvadó, Jorge
Keywords: Type 2 diabetes mellitus Type 2 diabetes Soluble transferrin receptor Risk factors Receptors, transferrin Predimed Obesity Nested case–control Nested case-control Middle aged Male Iron Humans Female Diet, mediterranean Diabetes mellitus, type 2 Case-control studies Body iron stores Blood glucose Biomarkers Aged, 80 and over Aged predimed
Abstract: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects.A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www.controlled-trials.com/ISRCTN35739639). Cases and controls were matched for age (? 67 vs. > 67 years), gender, dietary intervention group and BMI (? 27 vs. > 27 kg/m2 ).Waist circumference is the main determinant of sTfR concentrations in the whole sample (? = 0·476, P < 0·001), in the obese (? = 0·802, P < 0·001) and the nonobese (? = 0·455, P = 0·003). Furthermore, sTfR is directly associated with the risk of T2DM in obese individuals (OR = 2·79; 95% CI: 1·35-5·77, P = 0·005) and inversely associated in nonobese individuals (OR = 0·40; 95% CI: 0·20-0·79, P = 0·015).The association between sTfR levels and risk of T2DM in a population at high cardiovascular risk depend on the presence or absence of obesity. While in nonobese subjects elevated sTfR levels are associated with a decreased risk of developing T2DM, in obese subjects the risk increases. This suggests that obesity alters the relationship between sTfR and T2DM incidence.© 2017 Stichting European Society for Clinical Investigation Journal Foundation.
Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00142972
Author's mail: jose.fernandezs@urv.cat josep.basora@urv.cat nuria.aranda@urv.cat jose.fernandezs@urv.cat josep.basora@urv.cat jordi.salas@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0002-6717-7674 0000-0001-9708-747X 0000-0002-6717-7674 0000-0003-2700-7459 0000-0002-1758-0975
Record's date: 2025-03-22
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: European Journal Of Clinical Investigation. 47 (3): 221-230
APA: Fernandez-Cao, Jose C; Arija, Victoria; Aranda, Nuria; Basora, Josep; Diez-Espino, Javier; Estruch, Ramon; Fito, Montse; Corella, Dolores; Salas-Salva (2017). Soluble transferrin receptor and risk of type 2 diabetes in the obese and non-obese.. European Journal Of Clinical Investigation, 47(3), 221-230. DOI: 10.1111/eci.12725
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV