Author, as appears in the article.: Babio, Nancy; Ibarrola-Jurado, Nuria; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Waernberg, Julia; Salaverria, Itziar; Ortega-Calvo, Manuel; Estruch, Ramon; Serra-Majem, Lluis; Isabel Covas, Maria; Vicente Sorli, Jose; Salas-Salvado, Jordi
Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / IBARROLA JURADO, NURIA / Martín Lujan, Francisco Manuel / Salas Salvadó, Jorge
Keywords: Good health and well-being
Abstract: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS.Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n?=?4,377) and a prospective assessment (n?=?1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components.Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend<0.001). This association was also observed for all WBC subtypes, except for basophils. Compared to participants in the lowest quartile, those in the top quartile of leukocyte, neutrophil and lymphocyte count had an increased risk of MetS incidence. Leukocyte and neutrophil count were found to be strongly associated with the MetS components hypertriglyceridemia and low HDL-cholesterol. Likewise, lymphocyte counts were found to be associated with the incidence of the MetS components low HDL-cholesterol and high fasting glucose. An increase in the total WBC during the follow-up was also associated with an increased risk of MetS.Total WBC counts, and some subtypes, were positively associated with MetS as well as hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, all components of MetS.Controlled-Trials.comISRCTN35739639.
Thematic Areas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Author's mail: andres.diaz@urv.cat paco.martin@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0003-0359-3588 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-11-16
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058354
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Plos One. 8 (3): 467-e58354
APA: Babio, Nancy; Ibarrola-Jurado, Nuria; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Waernberg, Julia; Salaverria, Itziar; Ortega-Calvo, Manuel; Estr (2013). White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study. Plos One, 8(3), 467-e58354. DOI: 10.1371/journal.pone.0058354
Article's DOI: 10.1371/journal.pone.0058354
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications
Repositori URV