Articles producció científica> Ciències Mèdiques Bàsiques

White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study

  • Identification data

    Identifier: imarina:2656262
  • Authors:

    Babio N, Ibarrola-Jurado N, Bulló M, Martínez-González MÁ, Wärnberg J, Salaverría I, Ortega-Calvo M, Estruch R, Serra-Majem L, Covas MI, Sorli JV, Salas-Salvadó J, PREDIMED Study Investigators
  • Others:

    Author, as appears in the article.: Babio N, Ibarrola-Jurado N, Bulló M, Martínez-González MÁ, Wärnberg J, Salaverría I, Ortega-Calvo M, Estruch R, Serra-Majem L, Covas MI, Sorli JV, Salas-Salvadó J, PREDIMED Study Investigators
    Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / IBARROLA JURADO, NURIA / Martín Lujan, Francisco Manuel / Salas Salvadó, Jorge
    Keywords: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
    Abstract: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS.Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n?=?4,377) and a prospective assessment (n?=?1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components.Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend<0.001). This association was also observed for all WBC subtypes, except for basophils. Compared to participants in the lowest quartile, those in the top quartile of leukocyte, neutrophil and lymphocyte count had an increased risk of MetS incidence. Leukocyte and neutrophil count were found to be strongly associated with the MetS components hypertriglyceridemia and low HDL-cholesterol. Likewise, lymphocyte counts were found to be associated with the incidence of the MetS components low HDL-cholesterol and high fasting glucose. An increase in the total WBC during the follow-up was also associated with an increased risk of MetS.Total WBC counts, and some subtypes, were positively associated with MetS as well as hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, all components of MetS.Controlled-Trials.comISRCTN35739639.
    Thematic Areas: Administração pública e de empresas, ciências contábeis e turismo Administração, ciências contábeis e turismo Agricultural and biological sciences (miscellaneous) Anthropology Antropologia / arqueologia Archaeology Arquitetura, urbanismo e design Astronomia / física Biochemistry, genetics and molecular biology (miscellaneous) Biodiversidade Biology Biotecnología Ciência da computação Ciência de alimentos Ciência política e relações internacionais Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Ciências sociais aplicadas i Comunicação e informação Demography Direito Economia Educação Educação física Enfermagem Engenharias i Engenharias ii Engenharias iii Engenharias iv Ensino Environmental studies Farmacia General agricultural and biological sciences General biochemistry,genetics and molecular biology General medicine Geociências Geografía Historia History & philosophy of science Human geography and urban studies Interdisciplinar Interdisciplinary research in the social sciences Letras / linguística Linguística e literatura Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Multidisciplinary Multidisciplinary sciences Nutrição Odontología Planejamento urbano e regional / demografia Psicología Psychology Química Saúde coletiva Serviço social Sociología Sociology Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat andres.diaz@urv.cat paco.martin@urv.cat
    ISSN: 19326203
    Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277 0000-0002-7500-5629 0000-0003-0359-3588
    Record's date: 2023-02-22
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058354
    Papper original source: Plos One. 8 (3): 467-
    APA: Babio N, Ibarrola-Jurado N, Bulló M, Martínez-González MÁ, Wärnberg J, Salaverría I, Ortega-Calvo M, Estruch R, Serra-Majem L, Covas MI, Sorli JV, Sal (2013). White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study. Plos One, 8(3), 467-. DOI: 10.1371/journal.pone.0058354
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1371/journal.pone.0058354
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2013
    Publication Type: Journal Publications
  • Keywords:

    Agricultural and Biological Sciences (Miscellaneous),Biochemistry, Genetics and Molecular Biology (Miscellaneous),Biology,Medicine (Miscellaneous),Multidisciplinary,Multidisciplinary Sciences
    @infoAeu
    @residentesaeu
    @uroweb
    Etiqueta «#»
    Hashtag
    Administração pública e de empresas, ciências contábeis e turismo
    Administração, ciências contábeis e turismo
    Agricultural and biological sciences (miscellaneous)
    Anthropology
    Antropologia / arqueologia
    Archaeology
    Arquitetura, urbanismo e design
    Astronomia / física
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biodiversidade
    Biology
    Biotecnología
    Ciência da computação
    Ciência de alimentos
    Ciência política e relações internacionais
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Ciências sociais aplicadas i
    Comunicação e informação
    Demography
    Direito
    Economia
    Educação
    Educação física
    Enfermagem
    Engenharias i
    Engenharias ii
    Engenharias iii
    Engenharias iv
    Ensino
    Environmental studies
    Farmacia
    General agricultural and biological sciences
    General biochemistry,genetics and molecular biology
    General medicine
    Geociências
    Geografía
    Historia
    History & philosophy of science
    Human geography and urban studies
    Interdisciplinar
    Interdisciplinary research in the social sciences
    Letras / linguística
    Linguística e literatura
    Matemática / probabilidade e estatística
    Materiais
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Multidisciplinary
    Multidisciplinary sciences
    Nutrição
    Odontología
    Planejamento urbano e regional / demografia
    Psicología
    Psychology
    Química
    Saúde coletiva
    Serviço social
    Sociología
    Sociology
    Zootecnia / recursos pesqueiros
    19326203
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