Author, as appears in the article.: Becerra-Tomas, Nerea; Estruch, Ramon; Bullo, Monica; Casas, Rosa; Diaz-Lopez, Andres; Basora, Josep; Fito, Montserrat; Serra-Majem, Lluis; Salas-Salvado, Jordi
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Basora Gallisa, Josep / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Díaz López, Andres / Salas Salvadó, Jorge
Keywords: Good health and well-being
Abstract: Insulin resistance and secretion depend on calcium homeostasis. Cross-sectional studies have associated elevated serum calcium levels with markers of impaired glucose metabolism. However, only one prospective cohort study has demonstrated an increased risk of diabetes in individuals with increased serum calcium concentrations. The aim of the current study was to prospectively investigate the association between albumin-adjusted serum calcium concentrations and type 2 diabetes in subjects at high cardiovascular risk.Prospective assessment of participants from two Spanish PREDIMED study centers where serum calcium levels were measured at baseline and yearly during follow-up. Multivariate-adjusted Cox regression models were fitted to assess associations between baseline and changes during follow-up in serum calcium levels and relative risk of diabetes incidence.After a median follow-up of 4.78 years, 77 new cases of type 2 diabetes occurred. An increase in serum calcium levels during follow-up was related to an increased risk of diabetes. In comparison with individuals in the lowest tertile (-0.78 ± 0.29 mg/dL), the hazard ratio (HR) and 95% CI for diabetes incidence in individuals in the higher tertile of change (0.52 ± 0.13 mg/dL) during follow-up was 3.48 (95% CI 1.48-8.17; P for trend = 0.01). When albumin-adjusted serum calcium was analyzed as a continuous variable, per 1 mg/dL increase, the HR of diabetes incidence was 2.87 (95% CI 1.18-6.96; P value = 0.02). These associations remained significant after individuals taking calcium supplements or having calcium levels out of normal range had been excluded.An increase in serum calcium concentrations is associated with an increased risk of type 2 diabetes in individuals at high cardiovascular risk.© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
Thematic Areas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01495992
Author's mail: josep.basora@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-11-16
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Diabetes Care. 37 (11): 3084-3091
APA: Becerra-Tomas, Nerea; Estruch, Ramon; Bullo, Monica; Casas, Rosa; Diaz-Lopez, Andres; Basora, Josep; Fito, Montserrat; Serra-Majem, Lluis; Salas-Salva (2014). Increased serum calcium levels and risk of type 2 diabetes in individuals at high cardiovascular risk. Diabetes Care, 37(11), 3084-3091. DOI: 10.2337/dc14-0898
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV