Author, as appears in the article.: Arija, Victoria; Fernandez-Cao, Jose C; Basora, Josep; Bullo, Monica; Aranda, Nuria; Estruch, Ramon; Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi
Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Type 2 diabetes Soluble transferrin receptor Serum ferritin Body iron stores
Abstract: A prospective nested case-control study within the PREvention with MEDiterranean Diet (PREDIMED) was conducted to evaluate the relationship between excess body Fe (measured as serum ferritin (SF), soluble transferrin receptor (sTfR) and sTfR:ferritin ratio) and the risk of type 2 diabetes mellitus (T2DM) in a Mediterranean population at a high risk of CVD, without T2DM at the start of the study. The study contained 459 subjects, 153 with incident T2DM (cases) and 306 without incident T2DM (controls). The follow-up period was for 6.0 (interquartile range 3.9-6.5) years. For each incident diabetic subject, two subjects were selected as controls who were matched broadly for age as well as for sex, intervention group and BMI. We observed a relationship between SF values >257 ?g/l in males and >139 ?g/l in females and the risk of T2DM, following adjustment in the conditional logistic regression model for high-sensitivity C-reactive protein, fasting glucose and other components of the metabolic syndrome (OR 3.62, 95% CI 1.32, 19.95; P= 0.022). We also found an association between low sTfR:ferritin ratio levels and the incidence of T2DM (OR 3.02, 95% CI 1.09, 8.39; P= 0.042), but no association with sTfR (OR 1.29, 95% CI 0.51, 3.23; P= 0.722). Oxidative stress has been hypothesised to contribute to the development of insulin resistance and ?-cell dysfunction, the two key events in the clinical development of T2DM. Following adjustment for other risk factors for T2DM, excess body Fe (measured as SF and sTfR:ferritin ratio) was associated with an increased risk of developing T2DM in a Mediterranean population at a high risk of CVD.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Author's mail: josep.basora@urv.cat nuria.aranda@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0001-9708-747X 0000-0002-0218-7046 0000-0003-2700-7459 0000-0002-1758-0975
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/excess-body-iron-and-the-risk-of-type-2-diabetes-mellitus-a-nested-casecontrol-in-the-predimed-prevention-with-mediterranean-diet-study/D5D2893CB3F556885FBD9E85CFE4F6B5
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: British Journal Of Nutrition. 112 (11): 1896-1904
APA: Arija, Victoria; Fernandez-Cao, Jose C; Basora, Josep; Bullo, Monica; Aranda, Nuria; Estruch, Ramon; Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi (2014). Excess body iron and the risk of type 2 diabetes mellitus: A nested case-control in the PREDIMED (PREvention with MEDiterranean Diet) study. British Journal Of Nutrition, 112(11), 1896-1904. DOI: 10.1017/S0007114514002852
Article's DOI: 10.1017/S0007114514002852
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications