Articles producció científica> Medicina i Cirurgia

Benefits of the Mediterranean Diet: Insights From the PREDIMED Study

  • Identification data

    Identifier: imarina:2656960
    Authors:
    Martinez-Gonzalez, Miguel ASalas-Salvado, JordiEstruch, RamonCorella, DoloresFito, MontseRos, Emilio
    Abstract:
    The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4.8years; hazard ratios were 0.70 (95% CI, 0.53-0.91) for the MeDiet+EVOO and 0.70 (CI, 0.53-0.94) for the MeDiet+nuts compared to the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 non-diabetic participants were 0.60 (0.43-0.85) and 0.82 (0.61-1.10) for MeDiet+EVOO and MeDiet+nuts, respectively versus control. Significant improvements in classical and emerging CVD risk factors also supported a favorable effect of both MeDiets on blood pressure, insulin sensitivity, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis. In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes. Thus, the PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention. Copyright © 2015 Elsevier Inc. All rights reserved.
  • Others:

    Author, as appears in the article.: Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi; Estruch, Ramon; Corella, Dolores; Fito, Montse; Ros, Emilio
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Castro Salomó, Antoni / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
    Keywords: Type-2 diabetes Stroke Randomized trials Primary prevention Peripheral artery disease Mediterranean diet Dietary intervention Atrial fibrillation stroke randomized trials primary prevention peripheral artery disease mediterranean diet dietary intervention atrial fibrillation
    Abstract: The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4.8years; hazard ratios were 0.70 (95% CI, 0.53-0.91) for the MeDiet+EVOO and 0.70 (CI, 0.53-0.94) for the MeDiet+nuts compared to the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 non-diabetic participants were 0.60 (0.43-0.85) and 0.82 (0.61-1.10) for MeDiet+EVOO and MeDiet+nuts, respectively versus control. Significant improvements in classical and emerging CVD risk factors also supported a favorable effect of both MeDiets on blood pressure, insulin sensitivity, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis. In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes. Thus, the PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention. Copyright © 2015 Elsevier Inc. All rights reserved.
    Thematic Areas: Saúde coletiva Medicina ii Medicina i Interdisciplinar General medicine Engenharias iv Educação física Ciências biológicas ii Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00330620
    Author's mail: juanjose.cabre@urv.cat monica.bullo@urv.cat antoni.castro@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-1082-6861 0000-0002-0218-7046 0000-0001-5441-6333 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0033062015000286?via%3Dihub#!
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Progress In Cardiovascular Diseases. 58 (1): 50-60
    APA: Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi; Estruch, Ramon; Corella, Dolores; Fito, Montse; Ros, Emilio (2015). Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Progress In Cardiovascular Diseases, 58(1), 50-60. DOI: 10.1016/j.pcad.2015.04.003
    Article's DOI: 10.1016/j.pcad.2015.04.003
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Type-2 diabetes
    Stroke
    Randomized trials
    Primary prevention
    Peripheral artery disease
    Mediterranean diet
    Dietary intervention
    Atrial fibrillation
    stroke
    randomized trials
    primary prevention
    peripheral artery disease
    mediterranean diet
    dietary intervention
    atrial fibrillation
    Saúde coletiva
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Engenharias iv
    Educação física
    Ciências biológicas ii
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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