Author, as appears in the article.: Amor, Antonio J.; Serra-Mir, Merce; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Salas-Salvado, Jordi; Fito, Montserrat; Estruch, Ramon; Serra-Majem, Lluis; Aros, Fernando; Babio, Nancy; Ros, Emilio; Ortega, Emilio;PREDIMED Investigators
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Díaz López, Andres / IBARROLA JURADO, NURIA / MENA SÁNCHEZ, GUILLERMO / Salas Huetos, Albert / Salas Salvadó, Jorge
Keywords: Task-force Spanish men Relative validity Primary prevention Predimed Mediterranean diet Hdl-cholesterol Framingham?regicor equation Framingham-regicor equation European guidelines Euroaspire iii Coronary-artery-disease Clinical-practice Cardiovascular risk prediction Cardiovascular disease American-heart-association mediterranean diet framingham?regicor equation cardiovascular disease
predimed
predimed
Abstract: The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories.In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata (low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5% moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence was associated with CVD risk reduction regardless of risk strata (P>0.4 for interaction).Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non-high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be useful to reduce CVD independent of baseline risk.URL: http://www.Controlled-trials.com. Unique identifier: ISRCTN35739639.© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
Thematic Areas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20479980
Author's mail: albert.salas@urv.cat juanjose.cabre@urv.cat josep.basora@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat josep.basora@urv.cat monica.bullo@urv.cat
Author identifier: 0000-0001-5914-6862 0000-0003-1082-6861 0000-0002-7500-5629 0000-0002-4429-6507 0000-0003-3527-5277 0000-0003-2700-7459 0000-0002-0218-7046
Record's date: 2024-05-23
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.ahajournals.org/doi/10.1161/JAHA.116.004803
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of The American Heart Association. 6 (3): 004803-
APA: Amor, Antonio J.; Serra-Mir, Merce; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Salas-Salvado, Jordi; Fito, Montserrat; Estruch, Ramon; Serra-Maje (2017). Prediction of Cardiovascular Disease by the Framingham-REGICOR Equation in the High-Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different Risk Strata. Journal Of The American Heart Association, 6(3), 004803-. DOI: 10.1161/JAHA.116.004803
Article's DOI: 10.1161/JAHA.116.004803
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV