Author, as appears in the article.: Casas, Rosa; Urpi-Sarda, Mireia; Sacanella, Emilio; Arranz, Sara; Corella, Dolores; Castaner, Olga; Lamuela-Raventos, Rosa-Maria; Salas-Salvado, Jordi; Lapetra, Jose; Portillo, Maria P.; Estruch, Ramon;
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge / Urpi Sarda, Mireia
Keywords: Randomized-trial Pattern Markers Low-grade inflammation High-risk Cytokines Cardiovascular-disease Atherosclerosis Activation
Abstract: Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1? (P < 0.05; all) compared to LFD. IL-1?, IL-5, IL-7, IL-12p70, IL-18, TNF-?, IFN-?, GCSF, GMCSF, and ENA78 (P < 0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P < 0.05; both) in the MeDiet+nuts group. Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09629351
Author's mail: mireia.urpi@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Mediators Of Inflammation. 2017 (3674390): 3674390-
APA: Casas, Rosa; Urpi-Sarda, Mireia; Sacanella, Emilio; Arranz, Sara; Corella, Dolores; Castaner, Olga; Lamuela-Raventos, Rosa-Maria; Salas-Salvado, Jordi (2017). Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediators Of Inflammation, 2017(3674390), 3674390-. DOI: 10.1155/2017/3674390
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV