Articles producció científica> Bioquímica i Biotecnologia

Urinary H-1 Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a Subcohort from the PREDIMED study

  • Identification data

    Identifier: imarina:2828995
    Authors:
    Madrid-Gambin, FranciscoLlorach, RafaelVazquez-Fresno, RosaUrpi-Sarda, MireiaAlmanza-Aguilera, EnriqueGarcia-Aloy, MarEstruch, RamonCorella, DoloresAndres-Lacueva, Cristina
    Abstract:
    Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils, and beans), spot urine samples from a subcohort from the PREDIMED study were stratified using a validated food frequency questionnaire. Urine samples of nonpulse consumers (?4 g/day of pulse intake) and habitual pulse consumers (?25 g/day of pulse intake) were analyzed using a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through 16 metabolites coming from (i) choline metabolism, (ii) protein-related compounds, and (iii) energy metabolism (including lower urinary glucose). Stepwise logistic regression analysis was applied to design a combined model of pulse exposure, which resulted in glutamine, dimethylamine, and 3-methylhistidine. This model was evaluated by a receiver operating characteristic curve (AUC > 90% in both training and validation sets). The application of NMR-based metabolomics to reported pulse exposure highlighted new candidates for biomarkers of pulse consumption and the impact on energy metabolism, generating new hypotheses on energy modulation. Further intervention studies will confirm these findings.
  • Others:

    Author, as appears in the article.: Madrid-Gambin, Francisco; Llorach, Rafael; Vazquez-Fresno, Rosa; Urpi-Sarda, Mireia; Almanza-Aguilera, Enrique; Garcia-Aloy, Mar; Estruch, Ramon; Corella, Dolores; Andres-Lacueva, Cristina;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Urpi Sarda, Mireia
    Keywords: Roc curve Renal-failure Randomized-trial Pulses Population Obesity Nmr Metabolomics Mediterranean diet Legumes Insulin-resistance Health Gut microbiota Energy Choline metabolism Cardiovascular-disease Biomarkers Amino-acid-metabolism roc curve nmr metabolomics legumes energy choline metabolism biomarkers
    Abstract: Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils, and beans), spot urine samples from a subcohort from the PREDIMED study were stratified using a validated food frequency questionnaire. Urine samples of nonpulse consumers (?4 g/day of pulse intake) and habitual pulse consumers (?25 g/day of pulse intake) were analyzed using a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through 16 metabolites coming from (i) choline metabolism, (ii) protein-related compounds, and (iii) energy metabolism (including lower urinary glucose). Stepwise logistic regression analysis was applied to design a combined model of pulse exposure, which resulted in glutamine, dimethylamine, and 3-methylhistidine. This model was evaluated by a receiver operating characteristic curve (AUC > 90% in both training and validation sets). The application of NMR-based metabolomics to reported pulse exposure highlighted new candidates for biomarkers of pulse consumption and the impact on energy metabolism, generating new hypotheses on energy modulation. Further intervention studies will confirm these findings.
    Thematic Areas: Química Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar General chemistry Farmacia Engenharias iii Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15353893
    Author's mail: mireia.urpi@urv.cat
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jproteome.6b00860
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Proteome Research. 16 (4): 1483-1491
    APA: Madrid-Gambin, Francisco; Llorach, Rafael; Vazquez-Fresno, Rosa; Urpi-Sarda, Mireia; Almanza-Aguilera, Enrique; Garcia-Aloy, Mar; Estruch, Ramon; Core (2017). Urinary H-1 Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a Subcohort from the PREDIMED study. Journal Of Proteome Research, 16(4), 1483-1491. DOI: 10.1021/acs.jproteome.6b00860
    Article's DOI: 10.1021/acs.jproteome.6b00860
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Biochemical Research Methods,Biochemistry,Chemistry (Miscellaneous)
    Roc curve
    Renal-failure
    Randomized-trial
    Pulses
    Population
    Obesity
    Nmr
    Metabolomics
    Mediterranean diet
    Legumes
    Insulin-resistance
    Health
    Gut microbiota
    Energy
    Choline metabolism
    Cardiovascular-disease
    Biomarkers
    Amino-acid-metabolism
    roc curve
    nmr
    metabolomics
    legumes
    energy
    choline metabolism
    biomarkers
    Química
    Odontología
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General chemistry
    Farmacia
    Engenharias iii
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biodiversidade
    Biochemistry
    Biochemical research methods
    Astronomia / física
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