Articles producció científica> Ciències Mèdiques Bàsiques

Hepcidin levels and gastric cancer risk in the EPIC-EurGast study.

  • Identification data

    Identifier: imarina:2865459
    Handle: http://hdl.handle.net/20.500.11797/imarina2865459
  • Authors:

    Jakszyn P, Fonseca-Nunes A, Lujan-Barroso L, Aranda N, Tous M, Arija V, Cross A, Bueno-de-Mesquita HBA, Weiderpass E, Kühn T, Kaaks R, Sjöberg K, Ohlsson B, Tumino R, Palli D, Ricceri F, Fasanelli F, Krogh V, Mattiello A, Jenab M, Gunter M, Perez-Cornago A, Khaw KT, Tjønneland A, Olsen A, Overvad K, Trichopoulou A, Peppa E, Vasilopoulou E, Boeing H, Sánchez-Cantalejo E, Huerta JM, Dorronsoro M, Barricarte A, Quirós JM, Peeters PH, Agudo A
  • Others:

    Author, as appears in the article.: Jakszyn P, Fonseca-Nunes A, Lujan-Barroso L, Aranda N, Tous M, Arija V, Cross A, Bueno-de-Mesquita HBA, Weiderpass E, Kühn T, Kaaks R, Sjöberg K, Ohlsson B, Tumino R, Palli D, Ricceri F, Fasanelli F, Krogh V, Mattiello A, Jenab M, Gunter M, Perez-Cornago A, Khaw KT, Tjønneland A, Olsen A, Overvad K, Trichopoulou A, Peppa E, Vasilopoulou E, Boeing H, Sánchez-Cantalejo E, Huerta JM, Dorronsoro M, Barricarte A, Quirós JM, Peeters PH, Agudo A
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / TOUS MÁRQUEZ, MÒNICA
    Keywords: Iron homeostasis Hepcidin Gastric cancer Cohort study
    Abstract: Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l?=?0.96, 95% CI?=?0.93-0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: -69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.© 2017 UICC.
    Thematic Areas: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00207136
    Author's mail: nuria.aranda@urv.cat victoria.arija@urv.cat
    Author identifier: 0000-0001-9708-747X 0000-0002-1758-0975
    Record's date: 2023-02-18
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.30797
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Cancer. 141 (5): 945-951
    APA: Jakszyn P, Fonseca-Nunes A, Lujan-Barroso L, Aranda N, Tous M, Arija V, Cross A, Bueno-de-Mesquita HBA, Weiderpass E, Kühn T, Kaaks R, Sjöberg K, Ohls (2017). Hepcidin levels and gastric cancer risk in the EPIC-EurGast study.. International Journal Of Cancer, 141(5), 945-951. DOI: 10.1002/ijc.30797
    Article's DOI: 10.1002/ijc.30797
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Iron homeostasis
    Hepcidin
    Gastric cancer
    Cohort study
    Saúde coletiva
    Química
    Oncology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Cancer research
    Biotecnología
    Biodiversidade
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