Author, as appears in the article.: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M., Shivappa N., Wärnberg J., Gómez-Gracia E., Tur J.A., Salas-Salvadó J., Zulet M.A., Martínez J.A.
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Keywords: diet inflammation liver nafld Adults Association Cardiovascular-disease Consumption Diet Follow-up Hepatocellular-carcinoma Inflammation Liver Metabolic syndrome Nafld Nonalcoholic fatty liver Obesity Risk Systemic inflammation
Abstract: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-? and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Thematic Areas: Biotecnología Ciência de alimentos Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Critical care and intensive care medicine Educação física Enfermagem Engenharias iv Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Nutrição Nutrition & dietetics Nutrition and dietetics Odontología Química Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
ISSN: 02615614
Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2023-02-18
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(17)30238-8/abstract
Papper original source: Clinical Nutrition. 37 (5): 1736-1743
APA: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M. (2018). Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clinical Nutrition, 37(5), 1736-1743. DOI: 10.1016/j.clnu.2017.06.027
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.clnu.2017.06.027
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV