Articles producció científica> Bioquímica i Biotecnologia

Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

  • Identification data

    Identifier: imarina:2975271
    Authors:
    Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M., Shivappa N., Wärnberg J., Gómez-Gracia E., Tur J.A., Salas-Salvadó J., Zulet M.A., Martínez J.A.
    Abstract:
    To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-? and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.Copyright © 2017 Elsevier Ltd
  • Others:

    Author, as appears in the article.: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M., Shivappa N., Wärnberg J., Gómez-Gracia E., Tur J.A., Salas-Salvadó J., Zulet M.A., Martínez J.A.
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Keywords: Systemic inflammation Risk Obesity Nonalcoholic fatty liver Nafld Metabolic syndrome Liver Inflammation Hepatocellular-carcinoma Follow-up Diet Consumption Cardiovascular-disease Association Adults nafld liver inflammation diet
    Abstract: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-? and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02615614
    Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(17)30238-8/abstract
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 37 (5): 1736-1743
    APA: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M. (2018). Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clinical Nutrition, 37(5), 1736-1743. DOI: 10.1016/j.clnu.2017.06.027
    Article's DOI: 10.1016/j.clnu.2017.06.027
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Systemic inflammation
    Risk
    Obesity
    Nonalcoholic fatty liver
    Nafld
    Metabolic syndrome
    Liver
    Inflammation
    Hepatocellular-carcinoma
    Follow-up
    Diet
    Consumption
    Cardiovascular-disease
    Association
    Adults
    nafld
    liver
    inflammation
    diet
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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