Author, as appears in the article.: Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saul; Cofan, Montserrat; Calder, Philip C; Fito, Montserrat; Corella, Dolores; Salas-Salvado, Jordi; Ruiz-Canela, Miguel; Estruch, Ramon; Ros, Emilio; Sala-Vila, Aleix
Department: Bioquímica i Biotecnologia
URV's Author/s: GILABERT VALL, ROSA / Salas Salvadó, Jorge
Keywords: Variability; Triglycerides; Spain; Risk factors; Population; Plaque, atherosclerotic; Omega-3 index; Omega-3; Nutrition assessment; Myocardial-infarction; Middle aged; Male; Magnetic resonance imaging; Imaging; Humans; Fish; Female; Fatty-acids; Erythrocytes; Eicosapentaenoic acid; Disease; Diet; Cross-sectional studies; Cholesterol; Carotid intima-media thickness; Carotid artery diseases; Cardiovascular diseases; Body mass index; Biomarkers; Atherosclerosis; American-heart-association; Aged; imaging; fish; diet; atherosclerosis
Abstract: Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ?2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: jordi.salas@urv.cat
Record's date: 2025-02-17
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/9/9/1036
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 9 (9): E1036-
APA: Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saul; Cofan, Montserrat; Calder, Philip C; Fito, Montserrat; Corella, Dolores; Salas-Salvado, Jo (2017). Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk. Nutrients, 9(9), E1036-. DOI: 10.3390/nu9091036
Article's DOI: 10.3390/nu9091036
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV