Repositori URV

Author, as appears in the article.: Papandreou, Christopher; Becerra-Tomas, Nerea; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Aros, Fernando; Schroder, Helmut; Fito, Montserrat; Serra-Majem, Lluis; Lapetra, Jose; Fiol, Miguel; Ruiz-Canela, Miguel; Sorli, Jose V; Salas-Salvado, Jordi

Department: Bioquímica i Biotecnologia

URV's Author/s: Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge

Keywords: Sex difference Prospective study Predimed Observational study Obesity Nutritional assessment Mortality risk Mortality rate Mortality Malignant neoplasm Male Major clinical study Lentil Legumes Legume Impact Human Heart-disease Grain legume Fruit Food intake Food frequency questionnaire Follow up Female Disease association Dietary intake Diet Diabetic patient Countries Controlled study Cohort analysis Cohort Cardiovascular risk Cardiovascular mortality Cardiovascular Cancer mortality Cancer Bean Article All cause mortality Aged Adult mortality legumes cardiovascular cancer

Abstract: Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk.We prospectively assessed 7216 participants from the PREvención con DIeta MEDiterránea study. Dietary intake was assessed at baseline and yearly during follow-up by using a validated food frequency questionnaire.During a median follow-up of 6.0 years, 425 total deaths, 103 CVD deaths, 169 cancer deaths and 153 due to other-causes deaths occurred. Hazard ratios (HRs) [95% confidence interval (CI)] of CVD mortality were 1.52 (1.02-2.89) (P-trend = 0.034) and 2.23 (1.32-3.78) (P-trend = 0.002) for the 3rd tertile of total legumes and dry beans consumption, respectively, compared with the 1st tertile. When comparing extreme tertiles, higher total legumes and lentils consumption was associated with 49% (HR: 0.51; 95% CI: 0.31-0.84; P-trend = 0.009) and 37% (HR: 0.63; 95% CI: 0.40-0.98; P-trend = 0.049) lower risk of cancer mortality. Similar associations were observed for CVD death in males and for cancer death in males, obese and diabetic participants.These findings support the benefits of legumes consumption for cancer mortality prevention which may be counterbalanced by their higher risk for CVD mortality.The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02615614

Author's mail: nerea.becerra@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat

Author identifier: 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459

Record's date: 2024-10-12

Papper version: info:eu-repo/semantics/acceptedVersion

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical Nutrition. 38 (1): 348-356

APA: Papandreou, Christopher; Becerra-Tomas, Nerea; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Aros, Fe (2019). Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study. Clinical Nutrition, 38(1), 348-356. DOI: 10.1016/j.clnu.2017.12.019

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications