Articles producció científica> Bioquímica i Biotecnologia

Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study

  • Identification data

    Identifier: imarina:3194120
    Authors:
    Papandreou, ChristopherBecerra-Tomas, NereaBullo, MonicaAngel Martinez-Gonzalez, MiguelCorella, DoloresEstruch, RamonRos, EmilioAros, FernandoSchroder, HelmutFito, MontserratSerra-Majem, LluisLapetra, JoseFiol, MiguelRuiz-Canela, MiguelSorli, Jose VSalas-Salvado, Jordi
    Abstract:
    Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk.We prospectively assessed 7216 participants from the PREvención con DIeta MEDiterránea study. Dietary intake was assessed at baseline and yearly during follow-up by using a validated food frequency questionnaire.During a median follow-up of 6.0 years, 425 total deaths, 103 CVD deaths, 169 cancer deaths and 153 due to other-causes deaths occurred. Hazard ratios (HRs) [95% confidence interval (CI)] of CVD mortality were 1.52 (1.02-2.89) (P-trend = 0.034) and 2.23 (1.32-3.78) (P-trend = 0.002) for the 3rd tertile of total legumes and dry beans consumption, respectively, compared with the 1st tertile. When comparing extreme tertiles, higher total legumes and lentils consumption was associated with 49% (HR: 0.51; 95% CI: 0.31-0.84; P-trend = 0.009) and 37% (HR: 0.63; 95% CI: 0.40-0.98; P-trend = 0.049) lower risk of cancer mortality. Similar associations were observed for CVD death in males and for cancer death in males, obese and diabetic participants.These findings support the benefits of legumes consumption for cancer mortality prevention which may be counterbalanced by their higher risk for CVD mortality.The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.Copyright © 2018 Elsevier Ltd and European Society fo
  • Others:

    Author, as appears in the article.: Papandreou, Christopher; Becerra-Tomas, Nerea; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Aros, Fernando; Schroder, Helmut; Fito, Montserrat; Serra-Majem, Lluis; Lapetra, Jose; Fiol, Miguel; Ruiz-Canela, Miguel; Sorli, Jose V; Salas-Salvado, Jordi
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Keywords: Sex difference Prospective study Predimed Observational study Obesity Nutritional assessment Mortality risk Mortality rate Mortality Malignant neoplasm Male Major clinical study Lentil Legumes Legume Impact Human Heart-disease Grain legume Fruit Food intake Food frequency questionnaire Follow up Female Disease association Dietary intake Diet Diabetic patient Countries Controlled study Cohort analysis Cohort Cardiovascular risk Cardiovascular mortality Cardiovascular Cancer mortality Cancer Bean Article All cause mortality Aged Adult mortality legumes cardiovascular cancer
    Abstract: Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk.We prospectively assessed 7216 participants from the PREvención con DIeta MEDiterránea study. Dietary intake was assessed at baseline and yearly during follow-up by using a validated food frequency questionnaire.During a median follow-up of 6.0 years, 425 total deaths, 103 CVD deaths, 169 cancer deaths and 153 due to other-causes deaths occurred. Hazard ratios (HRs) [95% confidence interval (CI)] of CVD mortality were 1.52 (1.02-2.89) (P-trend = 0.034) and 2.23 (1.32-3.78) (P-trend = 0.002) for the 3rd tertile of total legumes and dry beans consumption, respectively, compared with the 1st tertile. When comparing extreme tertiles, higher total legumes and lentils consumption was associated with 49% (HR: 0.51; 95% CI: 0.31-0.84; P-trend = 0.009) and 37% (HR: 0.63; 95% CI: 0.40-0.98; P-trend = 0.049) lower risk of cancer mortality. Similar associations were observed for CVD death in males and for cancer death in males, obese and diabetic participants.These findings support the benefits of legumes consumption for cancer mortality prevention which may be counterbalanced by their higher risk for CVD mortality.The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02615614
    Author's mail: nerea.becerra@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(17)31439-5/abstract
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 38 (1): 348-356
    APA: Papandreou, Christopher; Becerra-Tomas, Nerea; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Aros, Fe (2019). Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study. Clinical Nutrition, 38(1), 348-356. DOI: 10.1016/j.clnu.2017.12.019
    Article's DOI: 10.1016/j.clnu.2017.12.019
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Sex difference
    Prospective study
    Predimed
    Observational study
    Obesity
    Nutritional assessment
    Mortality risk
    Mortality rate
    Mortality
    Malignant neoplasm
    Male
    Major clinical study
    Lentil
    Legumes
    Legume
    Impact
    Human
    Heart-disease
    Grain legume
    Fruit
    Food intake
    Food frequency questionnaire
    Follow up
    Female
    Disease association
    Dietary intake
    Diet
    Diabetic patient
    Countries
    Controlled study
    Cohort analysis
    Cohort
    Cardiovascular risk
    Cardiovascular mortality
    Cardiovascular
    Cancer mortality
    Cancer
    Bean
    Article
    All cause mortality
    Aged
    Adult
    mortality
    legumes
    cardiovascular
    cancer
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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