Articles producció científica> Ciències Mèdiques Bàsiques

Behavioral effects in mice of postnatal exposure to low-doses of 137-cesium and bisphenol A

  • Identification data

    Identifier: imarina:3387915
    Authors:
    Heredia, LuisBelles, MontserratLLovet, Maria IsabelDomingo, Jose LLinares, Victoria
    Abstract:
    Bisphenol A (BPA) is the most important plasticizer used in many household products such as polycarbonate plastics or epoxy resins. Public and scientific concerns exist regarding the possibility that the neonatal exposure to BPA may contribute to neurobehavioral disorders. On the other hand, there is little information on the effects of low doses of ionizing radiation during critical phases of postnatal brain development, as well as the combination of radiation and environmental chemicals. In this study, C57BL/6J mice were exposed to low doses of internal radiation ((137)Cs), and/or BPA on postnatal day 10 (PND10). At the age of two months, animals were submitted to several tests to assess anxiety, activity, learning, and memory. Results showed that exposure to (137)Cs, alone or in combination with BPA, increased the anxiety-like of the animals without changing the activity levels. Animals exposed to (137)Cs showed impaired learning, and spatial memory, an impairment that was not observed in the groups co-exposed to BPA.
  • Others:

    Author, as appears in the article.: Heredia, Luis; Belles, Montserrat; LLovet, Maria Isabel; Domingo, Jose L; Linares, Victoria
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Heredia Santaella, Luis / Linares Vidal, M. Victoria
    Keywords: Time factors Spatial memory Postnatal Plasticizers Phenols Motor activity Mice, inbred c57bl Mice Memory disorders Maze learning Ionizing radiation Ionising radiation Estudios de toxicidad perinatal y postnatal. Dose-response relationship, radiation Dose-response relationship, drug Cesium-137 Cesium radioisotopes Brain Bisphenol a Benzhydryl compounds Behavior, animal Behavior Anxiety Animals, newborn Animals Animal behavior Age factors 137-cesium mice ionizing radiation bisphenol a behavior 137-cesium
    Abstract: Bisphenol A (BPA) is the most important plasticizer used in many household products such as polycarbonate plastics or epoxy resins. Public and scientific concerns exist regarding the possibility that the neonatal exposure to BPA may contribute to neurobehavioral disorders. On the other hand, there is little information on the effects of low doses of ionizing radiation during critical phases of postnatal brain development, as well as the combination of radiation and environmental chemicals. In this study, C57BL/6J mice were exposed to low doses of internal radiation ((137)Cs), and/or BPA on postnatal day 10 (PND10). At the age of two months, animals were submitted to several tests to assess anxiety, activity, learning, and memory. Results showed that exposure to (137)Cs, alone or in combination with BPA, increased the anxiety-like of the animals without changing the activity levels. Animals exposed to (137)Cs showed impaired learning, and spatial memory, an impairment that was not observed in the groups co-exposed to BPA.
    Thematic Areas: Toxicology Saúde coletiva Química Psicología Pharmacology & pharmacy Odontología Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ensino Engenharias iii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0300483X
    Author's mail: luis.heredia@urv.cat luis.heredia@urv.cat joseluis.domingo@urv.cat mvictoria.linares@urv.cat montserrat.belles@urv.cat
    Author identifier: 0000-0001-9330-9418 0000-0001-9330-9418 0000-0001-6647-9470 0000-0003-4170-4197 0000-0002-9282-2989
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0300483X15300597
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Toxicology. 340 10-16
    APA: Heredia, Luis; Belles, Montserrat; LLovet, Maria Isabel; Domingo, Jose L; Linares, Victoria (2016). Behavioral effects in mice of postnatal exposure to low-doses of 137-cesium and bisphenol A. Toxicology, 340(), 10-16. DOI: 10.1016/j.tox.2015.12.002
    Article's DOI: 10.1016/j.tox.2015.12.002
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Pharmacology & Pharmacy,Toxicology
    Time factors
    Spatial memory
    Postnatal
    Plasticizers
    Phenols
    Motor activity
    Mice, inbred c57bl
    Mice
    Memory disorders
    Maze learning
    Ionizing radiation
    Ionising radiation
    Estudios de toxicidad perinatal y postnatal.
    Dose-response relationship, radiation
    Dose-response relationship, drug
    Cesium-137
    Cesium radioisotopes
    Brain
    Bisphenol a
    Benzhydryl compounds
    Behavior, animal
    Behavior
    Anxiety
    Animals, newborn
    Animals
    Animal behavior
    Age factors
    137-cesium
    mice
    ionizing radiation
    bisphenol a
    behavior
    137-cesium
    Toxicology
    Saúde coletiva
    Química
    Psicología
    Pharmacology & pharmacy
    Odontología
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência da computação
    Biotecnología
    Biodiversidade
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