Author, as appears in the article.: Heredia, Luis; Belles, Montserrat; LLovet, Maria Isabel; Domingo, Jose L; Linares, Victoria
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Heredia Santaella, Luis / Linares Vidal, M. Victoria
Keywords: Time factors Spatial memory Postnatal Plasticizers Phenols Motor activity Mice, inbred c57bl Mice Memory disorders Maze learning Ionizing radiation Ionising radiation Estudios de toxicidad perinatal y postnatal. Dose-response relationship, radiation Dose-response relationship, drug Cesium-137 Cesium radioisotopes Brain Bisphenol a Benzhydryl compounds Behavior, animal Behavior Anxiety Animals, newborn Animals Animal behavior Age factors 137-cesium mice ionizing radiation bisphenol a behavior 137-cesium
Abstract: Bisphenol A (BPA) is the most important plasticizer used in many household products such as polycarbonate plastics or epoxy resins. Public and scientific concerns exist regarding the possibility that the neonatal exposure to BPA may contribute to neurobehavioral disorders. On the other hand, there is little information on the effects of low doses of ionizing radiation during critical phases of postnatal brain development, as well as the combination of radiation and environmental chemicals. In this study, C57BL/6J mice were exposed to low doses of internal radiation ((137)Cs), and/or BPA on postnatal day 10 (PND10). At the age of two months, animals were submitted to several tests to assess anxiety, activity, learning, and memory. Results showed that exposure to (137)Cs, alone or in combination with BPA, increased the anxiety-like of the animals without changing the activity levels. Animals exposed to (137)Cs showed impaired learning, and spatial memory, an impairment that was not observed in the groups co-exposed to BPA.
Thematic Areas: Toxicology Saúde coletiva Química Psicología Pharmacology & pharmacy Odontología Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ensino Engenharias iii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0300483X
Author's mail: luis.heredia@urv.cat luis.heredia@urv.cat joseluis.domingo@urv.cat mvictoria.linares@urv.cat montserrat.belles@urv.cat
Author identifier: 0000-0001-9330-9418 0000-0001-9330-9418 0000-0001-6647-9470 0000-0003-4170-4197 0000-0002-9282-2989
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Toxicology. 340 10-16
APA: Heredia, Luis; Belles, Montserrat; LLovet, Maria Isabel; Domingo, Jose L; Linares, Victoria (2016). Behavioral effects in mice of postnatal exposure to low-doses of 137-cesium and bisphenol A. Toxicology, 340(), 10-16. DOI: 10.1016/j.tox.2015.12.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV