Author, as appears in the article.: Esplugas, Roser; Isabel Llovet, Maria; Belles, Montserrat; Serra, Noemi; Caries Vallve, Joan; Luis Domingo, Jose; Linares, Victoria
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
Keywords: Good health and well-being
Abstract: 137-Cesium (137Cs) is one of the most important distributed radionuclides after a nuclear accident. Humans are usually co-exposed to various environmental toxicants, being Bisphenol-A (BPA) one of them. Exposure to IR and BPA in early life is of major concern, due to the higher vulnerability of developing organs. We evaluate the renal and hepatic effects of low doses of ionizing radiation (IR) and BPA. Sixty male mice (C57BL/6J) were randomly assigned to six experimental groups (n=10) and received a single subcutaneous dose of 0.9% saline solution, 137Cs and/or BPA on postnatal day 10: control, BPA (25 ?g/kgbw), Cs4000 (4000 Bq 137Cs/kgbw), Cs8000 (8000 Bq 137Cs/kgbw), BPA/Cs4000 and BPA/Cs8000. At the age of two months, urines (24h) and blood samples were collected from animals of each group to determine biochemical parameters. Finally, kidneys and liver were removed to quantify DNA damage (8-OHdG), as well as to determine CYP1A2 mRNA expression. Data suggest that both BPA and 137Cs induced renal and liver damage evidenced by oxidative stress. However, when there is a co-exposure, it seems that there are compensatory mechanisms that may reverse the damage induced by each toxic itself. Notwithstanding, more studies are necessary to better understand the synergistic mechanisms behind.Copyright © 2018 Elsevier Ltd. All rights reserved.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Author's mail: roser.esplugas@urv.cat jc.vallve@urv.cat noemi.serra@urv.cat joseluis.domingo@urv.cat mvictoria.linares@urv.cat jc.vallve@urv.cat montserrat.belles@urv.cat
Author identifier: 0000-0002-5927-1644 0000-0002-2277-351X 0000-0001-6647-9470 0000-0003-4170-4197 0000-0002-9282-2989
Record's date: 2024-11-16
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691518301200?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food And Chemical Toxicology. 114 270-277
APA: Esplugas, Roser; Isabel Llovet, Maria; Belles, Montserrat; Serra, Noemi; Caries Vallve, Joan; Luis Domingo, Jose; Linares, Victoria (2018). Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and137Cs. Food And Chemical Toxicology, 114(), 270-277. DOI: 10.1016/j.fct.2018.02.046
Article's DOI: 10.1016/j.fct.2018.02.046
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV