Author, as appears in the article.: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A

Department: Bioquímica i Biotecnologia Medicina i Cirurgia

URV's Author/s: Arola Ferrer, Luis Maria / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria

Keywords: Systolic blood pressure Low weight molecular procyanidin Hdl-c Cardiovascular biomarkers low weight molecular procyanidin hdl-c cardiovascular biomarkers

Abstract: Background Oligopin¿ (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. Purpose The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects. Methods Between February 14 and May 31, 2014, eligible subjects were recruited from the outpatient clinics of Hospital Universitari Sant Joan (Reus, Spain). A total of 24 participants (mean age ± DS; 57.36 ± 11.25; 17 men) with stage-1-hypertension who were not receiving BP-lowering medication and LDL cholesterol < 4.88 mmol/l were randomized in a double-blind, placebo-controlled, crossover study. The subjects received 2 capsules/day with 75 mg of OP or placebo for 5-weeks. Results At 5-weeks, compared to the placebo, OP raised High Density Lipoprotein-cholesterol (HDL-c) by 14.06% (p = 0.012) and apolipoprotein A-1 by 8.12% (p = 0.038) and reduced the ratio of apolipoprotein B-100/A-1 by 10.26% (p = 0.046). Moreover, at 5-weeks, compared to the baseline, OP reduced the systolic BP by 6.36 mmHg (p = 0.014), and decreased ox-LDL concentrations by 31.72 U/l (p = 0.015). Conclusion At 5-weeks, the consumption of 150 mg/day of OP improve lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects.

Thematic Areas: Saúde coletiva Química Plant sciences Planejamento urbano e regional / demografia Pharmacology & pharmacy Pharmacology Pharmaceutical science Odontología Nutrição Molecular medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Integrative & complementary medicine General medicine Farmacia Engenharias ii Enfermagem Drug discovery Complementary and alternative medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09447113

Author's mail: elisabet.llaurado@urv.cat anna.pedret@urv.cat lluis.arola@urv.cat rosa.sola@urv.cat

Author identifier: 0000-0002-7439-9531 0000-0002-5327-932X 0000-0003-2767-1974 0000-0002-8359-235X

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0944711316301490

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Phytomedicine. 23 (12): 1451-1461

APA: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A (2016). Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial. Phytomedicine, 23(12), 1451-1461. DOI: 10.1016/j.phymed.2016.08.007

Article's DOI: 10.1016/j.phymed.2016.08.007

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications