Author, as appears in the article.: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A
Department: Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Arola Ferrer, Luis Maria / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria
Keywords: Systolic blood pressure Low weight molecular procyanidin Hdl-c Cardiovascular biomarkers low weight molecular procyanidin hdl-c cardiovascular biomarkers
Abstract: Background Oligopin¿ (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. Purpose The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects. Methods Between February 14 and May 31, 2014, eligible subjects were recruited from the outpatient clinics of Hospital Universitari Sant Joan (Reus, Spain). A total of 24 participants (mean age ± DS; 57.36 ± 11.25; 17 men) with stage-1-hypertension who were not receiving BP-lowering medication and LDL cholesterol < 4.88 mmol/l were randomized in a double-blind, placebo-controlled, crossover study. The subjects received 2 capsules/day with 75 mg of OP or placebo for 5-weeks. Results At 5-weeks, compared to the placebo, OP raised High Density Lipoprotein-cholesterol (HDL-c) by 14.06% (p = 0.012) and apolipoprotein A-1 by 8.12% (p = 0.038) and reduced the ratio of apolipoprotein B-100/A-1 by 10.26% (p = 0.046). Moreover, at 5-weeks, compared to the baseline, OP reduced the systolic BP by 6.36 mmHg (p = 0.014), and decreased ox-LDL concentrations by 31.72 U/l (p = 0.015). Conclusion At 5-weeks, the consumption of 150 mg/day of OP improve lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects.
Thematic Areas: Saúde coletiva Química Plant sciences Planejamento urbano e regional / demografia Pharmacology & pharmacy Pharmacology Pharmaceutical science Odontología Nutrição Molecular medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Integrative & complementary medicine General medicine Farmacia Engenharias ii Enfermagem Drug discovery Complementary and alternative medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09447113
Author's mail: anna.pedret@urv.cat elisabet.llaurado@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0002-5327-932X 0000-0002-7439-9531 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0944711316301490
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Phytomedicine. 23 (12): 1451-1461
APA: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A (2016). Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial. Phytomedicine, 23(12), 1451-1461. DOI: 10.1016/j.phymed.2016.08.007
Article's DOI: 10.1016/j.phymed.2016.08.007
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV