Author, as appears in the article.: García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A.
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Telomere Nutrigenomics Genetic polymorphism Diet nutrigenomics genetic polymorphism diet
Abstract: Background - The gene variant Pro/Ala (rs1801282) in the PPARγ2 has been associated with lower cardiovascular risk and greater benefit from lifestyle interventions. This polymorphism also seems to be associated with longer lifespan, but no information on telomere length (TL) is available. Our aim was to study the association between the Ala allele and changes in TL in high cardiovascular risk subjects and the potential interaction with a Mediterranean dietary pattern. Methods and Results - A total of 521 subjects (55-80 years) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped. Changes in TL, measured by quantitative real-time polymerase chain reaction (PCR), were assessed over 5 years of a nutritional intervention, which promoted adherence to the Mediterranean diet (MeDiet). Interestingly, Ala carriers showed lower telomere shortening after 5 years compared with the Pro/Pro genotype (P=0.031). This association was modulated by MeDiet because those Ala carriers who reported better conformity to the MeDiet exhibited increased TL (P<0.001). Moreover, a reduction in carbohydrate intake (≤9.5 g/d) resulted in increased TL among Ala carriers. Notably, an apparent gene-diet interaction was found through the observed changes in the MUFA+PUFA/carbohydrates ratio: as this ratio increased, TL lengthening was detected to a greater extent in the Ala carriers compared with the Pro/Pro subjects (P for interaction <0.001). Conclusions - The Pro12Ala polymorphism is associated with TL homeostasis after 5 years follow-up in subjects at high cardiovascular risk. In addition, a higher adherence to the MeDiet pattern strengthens the prevention of telomere shortening among Ala carriers. Clinical Trial Registration - www.controlled-trials.com; Unique Identifier: ISRCTN35739639. © 2014 American Heart Association, Inc.
Thematic Areas: Medicine (miscellaneous) Genetics (clinical) Genetics & heredity Genetics General medicine Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.114.000635
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Circulation-Cardiovascular Genetics. 8 (1): 91-99
APA: García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A. (2015). Pro12Ala polymorphism of the PPARγ2 gene interacts with a Mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial. Circulation-Cardiovascular Genetics, 8(1), 91-99. DOI: 10.1161/CIRCGENETICS.114.000635
Article's DOI: 10.1161/CIRCGENETICS.114.000635
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV