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Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth

  • Identification data

    Identifier: imarina:3661846
    Authors:
    Murphy M., Fernandez-Ballart J., Molloy A., Canals J.
    Abstract:
    Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother¿child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2¿10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 µmol/L) was categorized as moderately elevated and low-mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children.
  • Others:

    Author, as appears in the article.: Murphy M., Fernandez-Ballart J., Molloy A., Canals J.
    Department: Psicologia Ciències Mèdiques Bàsiques
    URV's Author/s: Canals Sans, Josefa / Fernández Ballart, Joan Domènech / Murphy, Michelle
    Keywords: Pregnancy Preconception Homocysteine Cognitive development preconception homocysteine cognitive development
    Abstract: Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother¿child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2¿10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 µmol/L) was categorized as moderately elevated and low-mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children.
    Thematic Areas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 17408695
    Author's mail: michelle.murphy@urv.cat josefa.canals@urv.cat
    Author identifier: 0000-0002-6304-6204 0000-0002-6209-9558
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.12289
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Maternal And Child Nutrition. 13 (2):
    APA: Murphy M., Fernandez-Ballart J., Molloy A., Canals J. (2017). Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth. Maternal And Child Nutrition, 13(2), -. DOI: 10.1111/mcn.12289
    Article's DOI: 10.1111/mcn.12289
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Nutrition & Dietetics,Nutrition and Dietetics,Obstetrics and Gynecology,Pediatrics,Pediatrics, Perinatology and Child Health,Public Health, Environmental and Occupational Health
    Pregnancy
    Preconception
    Homocysteine
    Cognitive development
    preconception
    homocysteine
    cognitive development
    Saúde coletiva
    Public health, environmental and occupational health
    Pediatrics, perinatology and child health
    Pediatrics
    Obstetrics and gynecology
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Enfermagem
    Ciências biológicas ii
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