Author, as appears in the article.: Murphy M., Fernandez-Ballart J., Molloy A., Canals J.
Department: Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Canals Sans, Josefa / Fernández Ballart, Joan Domènech / Murphy, Michelle
Keywords: Pregnancy Preconception Homocysteine Cognitive development preconception homocysteine cognitive development
Abstract: Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother¿child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2¿10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 µmol/L) was categorized as moderately elevated and low-mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children.
Thematic Areas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17408695
Author's mail: michelle.murphy@urv.cat josefa.canals@urv.cat
Author identifier: 0000-0002-6304-6204 0000-0002-6209-9558
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.12289
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Maternal And Child Nutrition. 13 (2):
APA: Murphy M., Fernandez-Ballart J., Molloy A., Canals J. (2017). Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth. Maternal And Child Nutrition, 13(2), -. DOI: 10.1111/mcn.12289
Article's DOI: 10.1111/mcn.12289
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications