Articles producció científica> Medicina i Cirurgia

Gene-environment interaction between the brain-derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis.

  • Identification data

    Identifier: imarina:3707346
    Authors:
    Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J.
    Abstract:
    The brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.We studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS). Dietary patterns were examined by a dietician. Physical activity, life stress and perceived stress were assessed by validated questionnaires. BDNF Val66Met polymorphism (rs6265) was genotyped. A gene-environment interaction was tested with multiple linear regression analysis while adjusting for covariates.Perceived stress was not associated with calorie intake in HS. In ARMS subjects, Met-carriers who presented low-perceived stress were associated with increased caloric intake. Conversely, those who presented high-perceived stress were associated with reduced caloric intake. In PD, perceived stress was neither associated with increased calorie intake without an effect by BDNF genotype nor a gene-environment interaction. Perceived stress was associated with food craving in PD patients, independent of genotype, and in ARMS or HS who were Val homozygous.This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis.© 2016 John Wiley & Sons Australia, Ltd.
  • Others:

    Author, as appears in the article.: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J.
    Department: Medicina i Cirurgia Infermeria
    URV's Author/s: Martorell Bonet, Lourdes / Ortega Sanz, Laura / Vilella Cuadrada, Elisabet
    Keywords: Stress Early psychosis Diet Brain-derived neurotrophic factor Bdnf val66met early psychosis diet brain-derived neurotrophic factor bdnf val66met bdnf val66met
    Abstract: The brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.We studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS). Dietary patterns were examined by a dietician. Physical activity, life stress and perceived stress were assessed by validated questionnaires. BDNF Val66Met polymorphism (rs6265) was genotyped. A gene-environment interaction was tested with multiple linear regression analysis while adjusting for covariates.Perceived stress was not associated with calorie intake in HS. In ARMS subjects, Met-carriers who presented low-perceived stress were associated with increased caloric intake. Conversely, those who presented high-perceived stress were associated with reduced caloric intake. In PD, perceived stress was neither associated with increased calorie intake without an effect by BDNF genotype nor a gene-environment interaction. Perceived stress was associated with food craving in PD patients, independent of genotype, and in ARMS or HS who were Val homozygous.This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis.© 2016 John Wiley & Sons Australia, Ltd.
    Thematic Areas: Psychiatry and mental health Psychiatry Psychiatric mental health Medicina ii Medicina i General medicine Ciencias sociales Biological psychiatry
    ISSN: 17517885
    Author's mail: lourdes.martorell@urv.cat elisabet.vilella@urv.cat laura.ortega@urv.cat
    Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919 0000-0003-2476-7700
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1111/eip.12371
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Early Intervention In Psychiatry. 12 (5): 811-820
    APA: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J. (2018). Gene-environment interaction between the brain-derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis.. Early Intervention In Psychiatry, 12(5), 811-820. DOI: 10.1111/eip.12371
    Article's DOI: 10.1111/eip.12371
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biological Psychiatry,Psychiatric Mental Health,Psychiatry,Psychiatry and Mental Health
    Stress
    Early psychosis
    Diet
    Brain-derived neurotrophic factor
    Bdnf val66met
    early psychosis
    diet
    brain-derived neurotrophic factor
    bdnf val66met
    bdnf val66met
    Psychiatry and mental health
    Psychiatry
    Psychiatric mental health
    Medicina ii
    Medicina i
    General medicine
    Ciencias sociales
    Biological psychiatry
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