Articles producció científica> Bioquímica i Biotecnologia

Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals

  • Identification data

    Identifier: imarina:3823858
    Authors:
    Gasull MCastell CPallarès NMiret CPumarega JTéllez-Plaza MLópez TSalas-Salvadó JLee DHGoday APorta M
    Abstract:
    © The Author(s) 2017. Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes - particularly, among individuals with a similar body mass index - could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, ?-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
  • Others:

    Author, as appears in the article.: Gasull M; Castell C; Pallarès N; Miret C; Pumarega J; Téllez-Plaza M; López T; Salas-Salvadó J; Lee DH; Goday A; Porta M
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Persistent organic pollutants Metabolically healthy obese Metabolic syndrome Metabolic phenotype Human biomonitoring Health survey Environmental pollutants/toxicity Environmental exposure/adverse effects
    Abstract: © The Author(s) 2017. Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes - particularly, among individuals with a similar body mass index - could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, ?-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
    Thematic Areas: Saúde coletiva Public, environmental & occupational health Planejamento urbano e regional / demografia Nutrição Medicine (all) Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Epidemiology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00029262
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://academic.oup.com/aje/article/187/3/494/3903147
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Epidemiology. 187 (3): 494-506
    APA: Gasull M; Castell C; Pallarès N; Miret C; Pumarega J; Téllez-Plaza M; López T; Salas-Salvadó J; Lee DH; Goday A; Porta M (2018). Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals. American Journal Of Epidemiology, 187(3), 494-506. DOI: 10.1093/aje/kwx267
    Article's DOI: 10.1093/aje/kwx267
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Epidemiology,Public, Environmental & Occupational Health
    Persistent organic pollutants
    Metabolically healthy obese
    Metabolic syndrome
    Metabolic phenotype
    Human biomonitoring
    Health survey
    Environmental pollutants/toxicity
    Environmental exposure/adverse effects
    Saúde coletiva
    Public, environmental & occupational health
    Planejamento urbano e regional / demografia
    Nutrição
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Epidemiology
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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