Articles producció científica> Bioquímica i Biotecnologia

Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention

  • Identification data

    Identifier: imarina:3823924
    Authors:
    Hernandez-Alonso, PabloGiardina, SimonaCanueto, DanielSalas-Salvado, JordiCanellas, NicolauBullo, Monica
    Abstract:
    © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: To examine whether a low-glycemic index (LGI) diet improves a set of plasma metabolites related to different metabolic diseases, and comparison to a high-glycemic index (HGI) diet and a low-fat (LF) diet. Methods and results: A parallel, randomized trial with three intervention diets: an LGI diet, an HGI diet, and an LF diet. A total of 122 adult overweight and obese subjects were enrolled in the study for 6 months. Blood samples were collected at baseline and at the end of the intervention. The plasma metabolomic profile of 102 subjects was analyzed using three different approaches: GC/quadrupole-TOF, LC/quadrupole-TOF, and nuclear magnetic resonance. Both univariate and multivariate analysis were performed. Serine levels were significantly higher following the LGI diet compared to both the HGI and LF diets (q = 0.002), whereas leucine (q = 0.015) and valine (q = 0.024) were lower in the LGI diet compared to the LF diet. A set of two sphingomyelins, two lysophosphatidylcholines, and six phosphatidylcholines were significantly modulated after the LGI diet compared to the HGI and LF diets (q < 0.05). Significant correlations between changes in plasma amino acids and lipid species with changes in body weight, glucose, insulin, and some inflammatory markers are also reported. Conclusion: These results suggest that an LGI diet modulates certain circulating amino acids and lipid levels. These findings may explain the health benefits attributed to LGI diets in metabolic diseases such as type 2 diabetes.
  • Others:

    Author, as appears in the article.: Hernandez-Alonso, Pablo; Giardina, Simona; Canueto, Daniel; Salas-Salvado, Jordi; Canellas, Nicolau; Bullo, Monica
    Department: Bioquímica i Biotecnologia Eng. Electrònica, Elèctrica i Automàtica
    URV's Author/s: Bulló Bonet, Mònica / Cañellas Alberich, Nicolau / Salas Salvadó, Jorge
    Keywords: Nutritional intervention Metabolomics Lipidomics Glycemic index metabolomics lipidomics glycemic index
    Abstract: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: To examine whether a low-glycemic index (LGI) diet improves a set of plasma metabolites related to different metabolic diseases, and comparison to a high-glycemic index (HGI) diet and a low-fat (LF) diet. Methods and results: A parallel, randomized trial with three intervention diets: an LGI diet, an HGI diet, and an LF diet. A total of 122 adult overweight and obese subjects were enrolled in the study for 6 months. Blood samples were collected at baseline and at the end of the intervention. The plasma metabolomic profile of 102 subjects was analyzed using three different approaches: GC/quadrupole-TOF, LC/quadrupole-TOF, and nuclear magnetic resonance. Both univariate and multivariate analysis were performed. Serine levels were significantly higher following the LGI diet compared to both the HGI and LF diets (q = 0.002), whereas leucine (q = 0.015) and valine (q = 0.024) were lower in the LGI diet compared to the LF diet. A set of two sphingomyelins, two lysophosphatidylcholines, and six phosphatidylcholines were significantly modulated after the LGI diet compared to the HGI and LF diets (q < 0.05). Significant correlations between changes in plasma amino acids and lipid species with changes in body weight, glucose, insulin, and some inflammatory markers are also reported. Conclusion: These results suggest that an LGI diet modulates certain circulating amino acids and lipid levels. These findings may explain the health benefits attributed to LGI diets in metabolic diseases such as type 2 diabetes.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat nicolau.canyellas@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-4856-8132
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700975
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Molecular Nutrition & Food Research. 63 (1): e1700975-
    APA: Hernandez-Alonso, Pablo; Giardina, Simona; Canueto, Daniel; Salas-Salvado, Jordi; Canellas, Nicolau; Bullo, Monica (2019). Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention. Molecular Nutrition & Food Research, 63(1), e1700975-. DOI: 10.1002/mnfr.201700975
    Article's DOI: 10.1002/mnfr.201700975
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Nutritional intervention
    Metabolomics
    Lipidomics
    Glycemic index
    metabolomics
    lipidomics
    glycemic index
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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