Author, as appears in the article.: Crespo Escobar P; Castillejo G; Martínez-Ojinaga E; Donat E; Polanco I; Mearin M; Ribes-Koninckx C

Department: Medicina i Cirurgia

URV's Author/s: Castillejo De Villasante, Gemma

Keywords: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag

Abstract: AIM: to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study. METHODS: prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically. RESULTS: twenty-six cases were diagnosed, all had a positive biopsy and serology; 21 had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI: 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males. CONCLUSIONS: the amount of gluten intake between 11 and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression.

Thematic Areas: Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Gastroenterology & hepatology Gastroenterology Farmacia Ciências biológicas ii Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 11300108

Author's mail: gemma.castillejo@urv.cat

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.reed.es/ArticuloFicha.aspx?id=2977&hst=0&idR=63&tp=1&AspxAutoDetectCookieSupport=1

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Revista Espanola De Enfermedades Digestivas. 110 (8): 493-499

APA: Crespo Escobar P; Castillejo G; Martínez-Ojinaga E; Donat E; Polanco I; Mearin M; Ribes-Koninckx C (2018). Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned. Revista Espanola De Enfermedades Digestivas, 110(8), 493-499. DOI: 10.17235/reed.2018.5324/2017

Article's DOI: 10.17235/reed.2018.5324/2017

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications