Articles producció científica> Psicologia

Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner

  • Identification data

    Identifier: imarina:4211853
    Authors:
    Guardia-Escote LBasaure PBlanco JCabré MPérez-Fernández CSánchez-Santed FDomingo JColomina M
    Abstract:
    © 2018 Elsevier Ltd Organophosphorus pesticides – and in particular chlorpyrifos (CPF) – are extensively used worldwide. They mainly exert their toxicity by targeting the cholinergic system. Several studies suggested that the gene coding for apolipoprotein E (apoE), which is a risk factor for several diseases, can also confer different vulnerability to toxic insults. This study was aimed at assessing the long-term effects of postnatal exposure to CPF on learning and memory as well as the expression levels of several genes involved in cholinergic neurotransmission in mice. Both male and female apoE4-TR and C57BL/6 mice were exposed to either 0 or 1 mg/kg/day of CPF by oral gavage using a micropipette on postnatal days 10–15. At 9 months, they were tested in a Morris Water Maze (MWM) and the gene expression in the frontal cortex and hippocampus was evaluated. Our results show that, in males, CPF had an effect on the spatial retention, while in females, it altered the expression levels of nicotinic receptors. Furthermore, apoE4-TR mice performed the worst during the MWM retention and presented low expression levels in a considerable number of cholinergic genes. Taken together, the current results reveal long-term effects in mice nine months after postnatal exposure to CPF, which are modulated by sex and apoE4 genotype.
  • Others:

    Author, as appears in the article.: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M
    Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia
    URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
    Keywords: Synaptic transmission Spatial memory Sex factors Receptors, nicotinic Receptors, muscarinic Pesticide Mice, transgenic Mice, inbred c57bl Maze learning Male Learning and memory Learning Insecticides Hippocampus Genotype Gene expression profiling Frontal lobe Female Cholinergic system Cholinergic synapses Chlorpyrifos Brain development Apolipoprotein e4 Apoe Animals learning and memory cholinergic system chlorpyrifos brain development apoe
    Abstract: © 2018 Elsevier Ltd Organophosphorus pesticides – and in particular chlorpyrifos (CPF) – are extensively used worldwide. They mainly exert their toxicity by targeting the cholinergic system. Several studies suggested that the gene coding for apolipoprotein E (apoE), which is a risk factor for several diseases, can also confer different vulnerability to toxic insults. This study was aimed at assessing the long-term effects of postnatal exposure to CPF on learning and memory as well as the expression levels of several genes involved in cholinergic neurotransmission in mice. Both male and female apoE4-TR and C57BL/6 mice were exposed to either 0 or 1 mg/kg/day of CPF by oral gavage using a micropipette on postnatal days 10–15. At 9 months, they were tested in a Morris Water Maze (MWM) and the gene expression in the frontal cortex and hippocampus was evaluated. Our results show that, in males, CPF had an effect on the spatial retention, while in females, it altered the expression levels of nicotinic receptors. Furthermore, apoE4-TR mice performed the worst during the MWM retention and presented low expression levels in a considerable number of cholinergic genes. Taken together, the current results reveal long-term effects in mice nine months after postnatal exposure to CPF, which are modulated by sex and apoE4 genotype.
    Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02786915
    Author's mail: maria.cabre@urv.cat joseluis.domingo@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat
    Author identifier: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0001-8016-0984 0000-0002-5619-4874
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691518307130?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food And Chemical Toxicology. 122 1-10
    APA: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M (2018). Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner. Food And Chemical Toxicology, 122(), 1-10. DOI: 10.1016/j.fct.2018.09.069
    Article's DOI: 10.1016/j.fct.2018.09.069
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Synaptic transmission
    Spatial memory
    Sex factors
    Receptors, nicotinic
    Receptors, muscarinic
    Pesticide
    Mice, transgenic
    Mice, inbred c57bl
    Maze learning
    Male
    Learning and memory
    Learning
    Insecticides
    Hippocampus
    Genotype
    Gene expression profiling
    Frontal lobe
    Female
    Cholinergic system
    Cholinergic synapses
    Chlorpyrifos
    Brain development
    Apolipoprotein e4
    Apoe
    Animals
    learning and memory
    cholinergic system
    chlorpyrifos
    brain development
    apoe
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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