Author, as appears in the article.: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia
URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / BLANCO GOMEZ, JUAN JOSE / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Ferrer, Josep / Domingo Roig, José Luis / Guardia Escoté, Laia
Keywords: Synaptic transmission Spatial memory Sex factors Receptors, nicotinic Receptors, muscarinic Pesticide Mice, transgenic Mice, inbred c57bl Maze learning Male Learning and memory Learning Insecticides Hippocampus Genotype Gene expression profiling Frontal lobe Female Cholinergic system Cholinergic synapses Chlorpyrifos Brain development Apolipoprotein e4 Apoe Animals learning and memory cholinergic system chlorpyrifos brain development apoe
Abstract: © 2018 Elsevier Ltd Organophosphorus pesticides – and in particular chlorpyrifos (CPF) – are extensively used worldwide. They mainly exert their toxicity by targeting the cholinergic system. Several studies suggested that the gene coding for apolipoprotein E (apoE), which is a risk factor for several diseases, can also confer different vulnerability to toxic insults. This study was aimed at assessing the long-term effects of postnatal exposure to CPF on learning and memory as well as the expression levels of several genes involved in cholinergic neurotransmission in mice. Both male and female apoE4-TR and C57BL/6 mice were exposed to either 0 or 1 mg/kg/day of CPF by oral gavage using a micropipette on postnatal days 10–15. At 9 months, they were tested in a Morris Water Maze (MWM) and the gene expression in the frontal cortex and hippocampus was evaluated. Our results show that, in males, CPF had an effect on the spatial retention, while in females, it altered the expression levels of nicotinic receptors. Furthermore, apoE4-TR mice performed the worst during the MWM retention and presented low expression levels in a considerable number of cholinergic genes. Taken together, the current results reveal long-term effects in mice nine months after postnatal exposure to CPF, which are modulated by sex and apoE4 genotype.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Author's mail: jordi.blanco@urv.cat josep.domingo@urv.cat mariateresa.colomina@urv.cat joseluis.domingo@urv.cat maria.cabre@urv.cat
Author identifier: 0000-0001-8016-0984 0000-0001-7213-4962 0000-0002-5619-4874 0000-0001-6647-9470 0000-0003-4124-8603
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691518307130?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food And Chemical Toxicology. 122 1-10
APA: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M (2018). Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner. Food And Chemical Toxicology, 122(), 1-10. DOI: 10.1016/j.fct.2018.09.069
Article's DOI: 10.1016/j.fct.2018.09.069
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV