Author, as appears in the article.: Arenas M., Rodríguez E., García-Heredia A., Fernández-Arroyo S., Sabater S., Robaina R., Gascón M., Rodríguez-Pla M., Cabré N., Luciano-Mateo F., Hernández-Aguilera A., Fort-Gallifa I., Camps J., Joven J.
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Arenas Prat, Meritxell / Camps Andreu, Jorge / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge
Keywords: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
Abstract: The aims of this study were to investigate changes in energy balance-associated metabolites associated with radiotherapy in patients with breast cancer, and to relate these changes to the clinical and pathological response-to-treatment. We studied 151 women with breast cancer who received radiotherapy following surgical excision of the tumor. Blood was obtained before and after the irradiation procedure. The control group was composed of 44 healthy women with a similar age distribution to that of the patients. We analyzed the concentrations of metabolites involved in glycolysis, citric acid cycle and amino acid metabolism using targeted quantitative metabolomics. Post-surgery, pre-radiotherapy, patients had major alterations in the serum concentrations of products of glycolysis, citric acid cycle and amino acid metabolism. The strongest alterations were decreases in serine, leucine and isoleucine concentrations. Alterations in metabolite levels were partially, or totally, reversed after irradiation; the concentrations of serine, leucine and isoleucine approached equivalence to those of the control group. Estrogen receptor-positive patients were those with lower concentrations, while triple negative patients had higher concentrations of these amino acids. The normalization of the amino acids serine, leucine and isoleucine concentrations could be clinically relevant because the normalization of these energy-balance metabolites would suggest that residual micro-metastatic disease had been effectively diminished by the radiotherapy, and may be an indicator of its efficacy.
Thematic Areas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Author's mail: jorge.camps@urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat
Author identifier: 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207474
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Plos One. 13 (11): e0207474-
APA: Arenas M., Rodríguez E., García-Heredia A., Fernández-Arroyo S., Sabater S., Robaina R., Gascón M., Rodríguez-Pla M., Cabré N., Luciano-Mateo F., Hern (2018). Metabolite normalization with local radiotherapy following breast tumor resection. Plos One, 13(11), e0207474-. DOI: 10.1371/journal.pone.0207474
Article's DOI: 10.1371/journal.pone.0207474
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications