Project code: 713679
Keywords: Risk Odds ratio Membrane lipids Incidence Humans Heart diseases Follow-up studies Fatty acids Diet, mediterranean Coronary disease Confidence intervals Chromatography, gas Cell membrane Case-control studies Body mass index Biomarkers Adult
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Arteriosclerosis Thrombosis And Vascular Biology. 39 (4): 819-825
APA: Papandreou, Christopher; Sala-Vila, Aleix; Galie, Serena; Muralidharan, Jananee; Estruch, Ramon; Fito, Montserrat; Razquin, Cristina; Corella, Dolores (2019). Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology, 39(4), 819-825. DOI: 10.1161/ATVBAHA.118.312073
Acronym: MFP-COFUND
Publication Type: Journal Publications
Author, as appears in the article.: Papandreou, Christopher; Sala-Vila, Aleix; Galie, Serena; Muralidharan, Jananee; Estruch, Ramon; Fito, Montserrat; Razquin, Cristina; Corella, Dolores; Ros, Emilio; Timiraos, Juan; Lapetra, Jose; Serra-Majem, Lluis; Carlos, Silvia; Castaner, Olga; Asensio, Eva M; Salas-Salvado, Jordi; Bullo, Monica
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Galiè, Serena / Muralidharan, Jananee / Salas Salvadó, Jorge
Abstract: Objective- To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. Approach and Results- This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28-0.69]), 59% (OR, 0.41 [95% CI, 0.25-0.65]), and 55% (OR, 0.45 [95% CI, 0.29-0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25-2.00]). Conclusions- Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.
Thematic Areas: Saúde coletiva Peripheral vascular disease Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 10498834
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Paper data publication: 7 Feb 2019
Link to the original source: https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312073
Funding program: European Union Horizon 2020
Article's DOI: 10.1161/ATVBAHA.118.312073
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Funding program action: Marie Skłodowska-Curie
Repositori URV