Author, as appears in the article.: Papandreou, Christopher; Li, Jun; Liang, Liming; Bullo, Monica; Zheng, Yan; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Razquin, Cristina; Clish, Clary; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Serra-Majem, Lluis; Rosique, Nuria; Martinez-Gonzalez, Miguel A; Hu, Frank B; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / ROSIQUE ESTEBAN, NÚRIA / Salas Salvadó, Jorge
Keywords: Good health and well-being
Abstract: © 2019, The Author(s). Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-11-16
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41598-019-39441-6
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Scientific Reports. 9 (1): 2892-
APA: Papandreou, Christopher; Li, Jun; Liang, Liming; Bullo, Monica; Zheng, Yan; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Razquin, Cristina; C (2019). Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Scientific Reports, 9(1), 2892-. DOI: 10.1038/s41598-019-39441-6
Article's DOI: 10.1038/s41598-019-39441-6
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV