e-ISSN: 2072-6643
Project code: 713679
Keywords: inflammation Middle aged Male Inflammation Humans Female Fatty acids Cytokines Cross-sectional studies Cell membranes Cell membrane Case-control studies Blood cells Aged, 80 and over Aged fatty acids cell membranes
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 11 (3): 576-
APA: Muralidharan, Jananee; Papandreou, Christopher; Sala-Vila, Aleix; Rosique-Esteban, Nuria; Fito, Montserrat; Estruch, Ramon; Angel Martinez-Gonzalez, M (2019). Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis. Nutrients, 11(3), 576-. DOI: 10.3390/nu11030576
Acronym: MFP-COFUND
First page: 576
Publication Type: Journal Publications
Author, as appears in the article.: Muralidharan, Jananee; Papandreou, Christopher; Sala-Vila, Aleix; Rosique-Esteban, Nuria; Fito, Montserrat; Estruch, Ramon; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Ros, Emilio; Razquin, Cristina; Castaner, Olga; Salas-Salvado, Jordi; Bullo, Monica
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Muralidharan, Jananee / ROSIQUE ESTEBAN, NÚRIA / Salas Salvadó, Jorge
Abstract: There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Paper data publication: 7 march 2019
Journal volume: 11
Link to the original source: https://www.mdpi.com/2072-6643/11/3/576
Funding program: European Union Horizon 2020
Article's DOI: 10.3390/nu11030576
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Funding program action: Marie Skłodowska-Curie
Repositori URV